| Entry |
|
|---|
| Name |
Dorzolamide (INN);
Trusopt (TN) |
|---|
| Formula |
C10H16N2O4S3
|
|---|
| Exact mass |
324.0272
|
|---|
| Mol weight |
324.44
|
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| Structure |
|
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| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG01135): | D00653<JP/US> |
|
|---|
| Efficacy |
Antiglaucoma, Carbonic anhydrase inhibitor |
|---|
| Comment |
Diuretic action
|
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| Target |
|
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| Pathway |
| hsa04964 | Proximal tubule bicarbonate reclamation |
|
|---|
| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
|---|
| Structure map |
| map07055 | Sulfonamide derivatives - overview |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EC Carbonic anhydrase inhibitors
S01EC03 Dorzolamide
D07871 Dorzolamide (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
DG01135 Dorzolamide
D07871 Dorzolamide
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01135 Dorzolamide
D07871 Dorzolamide
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01135 Dorzolamide
D07871 Dorzolamide
DG01639 CYP2C19 substrate
DG01135 Dorzolamide
D07871 Dorzolamide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01135 Dorzolamide
D07871 Dorzolamide
Target-based classification of drugs [BR:br08310]
Enzymes
Lyases (EC4)
Aldehyde-lyases
CA
D07871 Dorzolamide (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07871
Drug groups [BR:br08330]
Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
DG01135 Dorzolamide
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01135 Dorzolamide
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01135 Dorzolamide
DG01639 CYP2C19 substrate
DG01135 Dorzolamide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01135 Dorzolamide
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 C8y C 19.3200 -14.9100
2 C8y C 19.3200 -16.3100
3 S2x S 20.5100 -14.2800
4 S2x S 17.9900 -14.4900
5 C1y C 20.5100 -17.0100
6 C8x C 17.9900 -16.7300
7 C1y C 21.7000 -14.9100
8 O3c O 19.2500 -13.3700
9 O3c O 21.6300 -13.4400
10 C8y C 17.2200 -15.6100
11 C1x C 21.7000 -16.3100
12 N1b N 20.5100 -18.4100
13 C1a C 22.8900 -14.2800
14 S4a S 15.8200 -15.6100
15 C1b C 21.7000 -19.0400
16 N1a N 15.8200 -17.2200
17 O3c O 15.8200 -14.2800
18 O3c O 14.3500 -15.6100
19 C1a C 21.7314 -20.4396
BOND 20
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 3 9 2
9 4 10 1
10 5 11 1
11 5 12 1 #Down
12 7 13 1 #Up
13 10 14 1
14 12 15 1
15 14 16 1
16 14 17 2
17 14 18 2
18 6 10 2
19 7 11 1
20 15 19 1
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