| Entry |
|
|---|
| Name |
Efonidipine (INN) |
|---|
| Formula |
C34H38N3O7P
|
|---|
| Exact mass |
631.2447
|
|---|
| Mol weight |
631.6552
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01573 Calcium channel T type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
|
|---|
| Remark |
| Product (DG01382): | D01604<JP> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01382 Efonidipine
D07886 Efonidipine
DG01573 Calcium channel T type blocker
DG01382 Efonidipine
D07886 Efonidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG01382 Efonidipine
D07886 Efonidipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D07886 Efonidipine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01382 Efonidipine
DG01573 Calcium channel T type blocker
DG01382 Efonidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG01382 Efonidipine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 45
1 C1y C 21.2100 -16.5900
2 C2y C 22.4000 -15.8900
3 C2y C 19.9500 -15.8900
4 C8y C 21.2100 -17.9900
5 C2y C 22.4000 -14.4900
6 C7a C 23.5900 -16.5900
7 C2y C 19.9500 -14.4900
8 P1b P 18.7600 -16.5900
9 C8x C 22.4000 -18.6900
10 C8x C 19.9500 -18.6900
11 N1x N 21.2100 -13.7900
12 C1a C 23.5900 -13.7200
13 O7a O 24.7800 -15.8900
14 O6a O 23.5900 -17.9900
15 C1a C 18.7600 -13.7900
16 C8y C 22.4000 -20.0900
17 C8x C 19.9500 -20.0900
18 C1b C 26.0400 -16.5900
19 C8x C 21.2100 -20.7900
20 N2b N 23.5900 -20.7900 #+
21 C1b C 27.2300 -15.8200
22 O3a O 24.9900 -19.9500
23 O3a O 23.5900 -22.1900 #-
24 O2x O 18.7600 -17.9900
25 C1x C 17.5000 -18.6900
26 C1z C 16.3100 -17.9900
27 C1x C 16.3100 -16.5900
28 O2x O 17.5700 -15.8900
29 O3b O 18.7600 -15.1900
30 N1c N 28.4200 -16.5200
31 C1b C 29.6800 -15.8900
32 C8y C 30.8700 -16.5200
33 C8x C 32.0600 -15.8900
34 C8x C 33.2500 -16.5900
35 C8x C 33.2500 -17.9200
36 C8x C 32.0600 -18.6200
37 C8x C 30.8700 -17.9200
38 C8y C 28.4200 -17.9200
39 C8x C 29.6100 -18.6200
40 C8x C 29.6100 -20.0200
41 C8x C 28.4200 -20.7200
42 C8x C 27.2300 -20.0200
43 C8x C 27.2300 -18.6200
44 C1a C 15.0500 -18.6900
45 C1a C 15.1200 -17.2900
BOND 49
1 20 22 2
2 20 23 1
3 7 11 1
4 17 19 2
5 1 2 1
6 1 3 1
7 1 4 1
8 8 24 1
9 24 25 1
10 25 26 1
11 26 27 1
12 27 28 1
13 28 8 1
14 2 5 2
15 8 29 2
16 2 6 1
17 3 7 2
18 3 8 1
19 21 30 1
20 4 9 1
21 30 31 1
22 4 10 2
23 31 32 1
24 5 11 1
25 5 12 1
26 6 13 1
27 6 14 2
28 7 15 1
29 32 33 2
30 33 34 1
31 34 35 2
32 35 36 1
33 36 37 2
34 37 32 1
35 9 16 2
36 30 38 1
37 10 17 1
38 13 18 1
39 16 19 1
40 16 20 1
41 18 21 1
42 38 39 2
43 39 40 1
44 40 41 2
45 41 42 1
46 42 43 2
47 43 38 1
48 26 44 1
49 26 45 1
|
|---|
