| Entry |
|
|---|
| Name |
Esmolol (INN) |
|---|
| Formula |
C16H25NO4
|
|---|
| Exact mass |
295.1784
|
|---|
| Mol weight |
295.374
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
|
|---|
| Remark |
| Product (DG00318): | D00644<JP/US> |
|
|---|
| Efficacy |
Antiarrhythmic, beta1-Adrenergic receptor antagonist |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AB Beta blocking agents, selective
C07AB09 Esmolol
D07916 Esmolol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00318 Esmolol
D07916 Esmolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00318 Esmolol
D07916 Esmolol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D07916 Esmolol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG00318 Esmolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
DG00318 Esmolol
|
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| Other DBs |
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| KCF data |
ATOM 21
1 C1c C 25.0600 -24.2900
2 C1a C 26.2724 -24.9900
3 N1b N 23.8476 -24.9900
4 C1a C 25.0600 -22.8900
5 C1b C 22.6521 -24.2996
6 C1c C 21.4647 -24.9851
7 C1b C 20.2735 -24.2971
8 O1a O 21.4645 -26.3898
9 O2a O 19.0840 -24.9838
10 C8y C 19.0840 -26.3838
11 C8x C 17.8886 -27.0742
12 C8x C 17.8889 -28.4742
13 C8y C 19.1014 -29.1740
14 C8x C 20.2968 -28.4836
15 C8x C 20.2966 -27.0836
16 C1b C 19.1016 -30.5900
17 C1b C 17.8955 -31.2865
18 C7a C 16.7030 -30.5980
19 O7a O 15.5144 -31.2844
20 O6a O 16.7028 -29.1903
21 C1a C 14.3236 -30.5969
BOND 21
1 1 2 1
2 1 3 1
3 1 4 1
4 3 5 1
5 5 6 1
6 6 7 1
7 6 8 1
8 7 9 1
9 9 10 1
10 10 11 2
11 11 12 1
12 12 13 2
13 13 14 1
14 14 15 2
15 10 15 1
16 13 16 1
17 16 17 1
18 17 18 1
19 18 19 1
20 18 20 2
21 19 21 1
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