KEGG DRUG: Flecainide

DRUG: Flecainide

Entry

D07962                      Drug

Name

Flecainide (INN)

Formula

C17H20F6N2O3

Exact mass

414.1378

Mol weight

414.3427

Structure

Simcomp

Class

Cardiovascular agent
DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
DG01644  CYP2D6 substrate

Remark

Same as:

C07001

ATC code:

C01BC04

Chemical structure group:

DG00201

Product (DG00201):

D00638<JP/US>

Efficacy

Antiarrhythmic, Sodium channel blocker

Target

SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]

Pathway

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04728

Dopaminergic synapse

Metabolism

Enzyme: CYP2D6 [HSA:1565]

Interaction

Structure map

map07037

Antiarrhythmic drugs

map07231

Sodium channel blocking drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC04 Flecainide
      D07962  Flecainide (INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00201  Flecainide
      D07962  Flecainide
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00201  Flecainide
    D07962  Flecainide
Target-based classification of drugs [BR:br08310]
Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D07962  Flecainide (INN)
    SCN2A
     D07962  Flecainide (INN)
    SCN3A
     D07962  Flecainide (INN)
    SCN4A
     D07962  Flecainide (INN)
    SCN5A
     D07962  Flecainide (INN)
    SCN8A
     D07962  Flecainide (INN)
    SCN9A
     D07962  Flecainide (INN)
    SCN10A
     D07962  Flecainide (INN)
    SCN11A
     D07962  Flecainide (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D07962
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00201  Flecainide
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00201  Flecainide

Other DBs

CAS:	54143-55-4

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        28
            1   C1x C    18.1300  -17.2900
            2   C1x C    18.1300  -18.6900
            3   N1x N    19.3900  -19.3900
            4   C1y C    20.5800  -18.6900
            5   C1x C    20.5800  -17.2900
            6   C1x C    19.3900  -16.5900
            7   C1b C    21.8400  -19.3900
            8   N1b N    23.0300  -18.6900
            9   C5a C    24.2200  -19.3900
            10  C8y C    25.4100  -18.6900
            11  O5a O    24.2200  -20.7900
            12  C8y C    26.6000  -19.3900
            13  C8x C    27.7900  -18.6900
            14  C8x C    27.7900  -17.2900
            15  C8y C    26.6000  -16.5900
            16  C8x C    25.4100  -17.2900
            17  O2a O    26.6000  -15.1900
            18  C1b C    27.8600  -14.4200
            19  C1d C    29.0500  -15.1200
            20  X   F    30.2400  -15.8200
            21  X   F    28.3500  -16.3800
            22  X   F    29.7500  -13.9300
            23  O2a O    26.6000  -20.7900
            24  C1b C    27.7900  -21.4900
            25  C1d C    28.9800  -20.7900
            26  X   F    30.1700  -20.0900
            27  X   F    29.6800  -21.9800
            28  X   F    28.2800  -19.5300
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   10  16 1
            18   15  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 1
            23   19  22 1
            24   12  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   25  27 1
            29   25  28 1

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