| Entry |
|
|---|
| Name |
Fluphenazine (INN);
Moditen (TN) |
|---|
| Formula |
C22H26F3N3OS
|
|---|
| Exact mass |
437.1749
|
|---|
| Mol weight |
437.5216
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00874): | D00791<US> D00793<JP/US> D02163<JP> |
|
|---|
| Efficacy |
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB02 Fluphenazine
D07977 Fluphenazine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00874 Fluphenazine
D07977 Fluphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00874 Fluphenazine
D07977 Fluphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00874 Fluphenazine
D07977 Fluphenazine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D07977 Fluphenazine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07977
Prodrugs [br08324.html]
D07977
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00874 Fluphenazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00874 Fluphenazine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00874 Fluphenazine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 30
1 C8y C 20.5100 -20.3700
2 N1y N 21.7000 -19.6700
3 C8y C 20.5100 -21.7700
4 C8x C 19.2500 -19.6700
5 C8y C 22.8900 -20.4400
6 C1b C 21.7000 -18.2700
7 S2x S 21.7000 -22.4700
8 C8x C 19.2500 -22.4700
9 C8x C 18.0600 -20.4400
10 C8y C 22.8900 -21.7700
11 C8x C 24.1500 -19.7400
12 C1b C 22.8900 -17.5700
13 C8x C 18.0600 -21.7700
14 C8x C 24.1500 -22.4700
15 C8y C 25.3400 -20.4400
16 C1b C 22.8900 -16.1700
17 C8x C 25.3400 -21.7700
18 N1y N 24.1500 -15.4700
19 C1x C 24.0800 -14.0700
20 C1x C 25.3400 -16.1700
21 C1x C 25.3400 -13.3700
22 C1x C 26.6000 -15.4700
23 N1y N 26.6000 -14.0700
24 C1b C 27.8600 -13.4400
25 C1b C 29.0500 -14.1400
26 O1a O 30.3100 -13.4400
27 C1d C 26.6000 -19.7400
28 X F 27.7200 -18.9700
29 X F 27.2300 -20.8600
30 X F 25.8300 -18.4800
BOND 33
1 18 19 1
2 18 20 1
3 19 21 1
4 20 22 1
5 21 23 1
6 23 24 1
7 7 10 1
8 9 13 1
9 15 17 1
10 22 23 1
11 1 2 1
12 1 3 2
13 1 4 1
14 2 5 1
15 2 6 1
16 3 7 1
17 3 8 1
18 4 9 2
19 5 10 2
20 5 11 1
21 6 12 1
22 8 13 2
23 10 14 1
24 11 15 2
25 12 16 1
26 14 17 2
27 16 18 1
28 24 25 1
29 25 26 1
30 15 27 1
31 27 28 1
32 27 29 1
33 27 30 1
|
|---|
