| Entry |
|
|---|
| Name |
Fluticasone (INN);
Fluticaps (TN) |
|---|
| Formula |
C22H27F3O4S
|
|---|
| Exact mass |
444.1582
|
|---|
| Mol weight |
444.5076
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00420): | D01708<JP/US> D06315<JP/US> |
|
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| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC17 Fluticasone
D07981 Fluticasone (INN)
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD08 Fluticasone
D07981 Fluticasone (INN)
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
R03BA Glucocorticoids
R03BA05 Fluticasone
D07981 Fluticasone (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00420 Fluticasone
D07981 Fluticasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00420 Fluticasone
D07981 Fluticasone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07981 Fluticasone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07981
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00420 Fluticasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00420 Fluticasone
|
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| Other DBs |
|
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| KCF data |
ATOM 30
1 C2x C 19.5739 -28.3860
2 C5x C 19.5739 -29.7339
3 C2x C 20.7799 -30.4434
4 C2y C 21.9150 -29.7339
5 C1z C 21.9150 -28.3860
6 C2x C 20.7799 -27.7475
7 C1y C 23.1211 -30.4434
8 C1x C 24.3271 -29.7339
9 C1y C 24.3271 -28.3860
10 C1z C 23.1211 -27.7475
11 C1y C 25.3913 -27.7475
12 C1z C 25.3913 -26.3996
13 C1x C 24.3271 -25.6901
14 C1y C 23.1211 -26.3996
15 C1x C 27.7324 -27.7475
16 C1y C 27.7324 -26.3996
17 C1z C 26.5264 -25.6901
18 O5x O 18.4388 -30.4434
19 C1a C 21.9150 -27.0381
20 X F 23.1211 -29.0245
21 O1a O 21.9150 -25.6901
22 C1a C 25.3913 -24.9807
23 O1a O 27.9452 -24.7679
24 C1a C 29.1513 -26.3996
25 X F 23.1211 -31.8622
26 C5a C 26.5264 -24.2713
27 O5a O 27.7551 -23.5618
28 S2a S 25.2976 -23.5618
29 C1b C 24.0860 -24.2615
30 X F 22.8826 -23.5668
BOND 33
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 10 20 1 #Down
24 14 21 1 #Up
25 12 22 1 #Up
26 17 23 1 #Down
27 16 24 1 #Down
28 7 25 1 #Down
29 17 26 1 #Up
30 26 27 2
31 26 28 1
32 28 29 1
33 29 30 1
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