KEGG   DRUG: Fluvoxamine
Entry
D07984                      Drug                                   
Name
Fluvoxamine (INN)
Formula
C15H21F3N2O2
Exact mass
318.1555
Mol weight
318.3347
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01659  Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Metabolizing enzyme inhibitor
 DG01634  CYP1A2 inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
 DG01645  CYP2D6 inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor
Remark
Same as: C07571
ATC code: N06AB08
Chemical structure group: DG00946
Product (DG00946): D00824<JP/US>
Efficacy
Antidepressant, Selective serotonin reuptake inhibitor (SSRI)
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP1A2 [HSA:1544], CYP2C19 [HSA:1557]; CYP2C9 [HSA:1559], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB08 Fluvoxamine
      D07984  Fluvoxamine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00946  Fluvoxamine
    D07984  Fluvoxamine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00946  Fluvoxamine
    D07984  Fluvoxamine
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00946  Fluvoxamine
    D07984  Fluvoxamine
  DG01643  CYP2C9 inhibitor
   DG00946  Fluvoxamine
    D07984  Fluvoxamine
  DG01933  CYP2C19 inhibitor
   DG00946  Fluvoxamine
    D07984  Fluvoxamine
  DG01645  CYP2D6 inhibitor
   DG00946  Fluvoxamine
    D07984  Fluvoxamine
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    DG00946  Fluvoxamine
     D07984  Fluvoxamine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D07984  Fluvoxamine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07984
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01659  Selective serotonin reuptake inhibitor (SSRI)
   DG00946  Fluvoxamine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00946  Fluvoxamine
 Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   DG00946  Fluvoxamine
  DG01643  CYP2C9 inhibitor
   DG00946  Fluvoxamine
  DG01933  CYP2C19 inhibitor
   DG00946  Fluvoxamine
  DG01645  CYP2D6 inhibitor
   DG00946  Fluvoxamine
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    DG00946  Fluvoxamine
Other DBs
CAS: 54739-18-3
PubChem: 96024678
ChEBI: 5138
PDB-CCD: FVX[PDBj]
LigandBox: D07984
NIKKAJI: J11.936I
KCF data

ATOM        22
            1   C8y C    19.9500  -16.8000
            2   C8x C    19.9500  -18.2000
            3   C8x C    21.1400  -18.9000
            4   C8y C    22.4000  -18.2000
            5   C8x C    22.4000  -16.8000
            6   C8x C    21.1400  -16.1000
            7   C1d C    18.7600  -16.1000
            8   X   F    17.5000  -15.4000
            9   X   F    19.3900  -14.8400
            10  X   F    18.1300  -17.3600
            11  C2c C    23.5900  -18.9000
            12  C1b C    24.8500  -18.2000
            13  N2b N    23.5900  -20.3000
            14  O2a O    24.8500  -21.0000
            15  C1b C    26.0400  -20.3000
            16  C1b C    27.2300  -21.0000
            17  N1a N    28.4200  -20.3000
            18  C1b C    25.9700  -18.9000
            19  C1b C    27.2300  -18.2000
            20  C1b C    28.4200  -18.9000
            21  O2a O    29.6100  -18.2000
            22  C1a C    30.8000  -18.9000
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     7   9 1
            10    7  10 1
            11    4  11 1
            12   11  12 1
            13   11  13 2
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   12  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1

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