KEGG   DRUG: Losartan
Entry
D08146                      Drug                                   
Name
Losartan (INN);
Losartic (TN)
Formula
C22H23ClN6O
Exact mass
422.1622
Mol weight
422.9106
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
 DG03231  Antihypertensive
  DG01495  Angiotensin II receptor antagonist
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Same as: C07072
ATC code: C09CA01
Chemical structure group: DG00348
Product (DG00348): D00357<JP/US>
Efficacy
Antihypertensive, Angiotensin II receptor antagonist
Target
AGTR1 [HSA:185] [KO:K04166]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07229  Angiotensin receptor and endothelin receptor antagonists
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
    C09CA Angiotensin II receptor blockers (ARBs), plain
     C09CA01 Losartan
      D08146  Losartan (INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01495  Angiotensin II receptor antagonist
    DG00348  Losartan
     D08146  Losartan
  DG03231  Antihypertensive
   DG01495  Angiotensin II receptor antagonist
    DG00348  Losartan
     D08146  Losartan
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG00348  Losartan
    D08146  Losartan
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D08146  Losartan (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08146
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01495  Angiotensin II receptor antagonist
    DG00348  Losartan
  DG03231  Antihypertensive
   DG01495  Angiotensin II receptor antagonist
    DG00348  Losartan
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   DG00348  Losartan
Other DBs
CAS: 114798-26-4
PubChem: 96024836
ChEBI: 6541
PDB-CCD: LSN[PDBj]
LigandBox: D08146
NIKKAJI: J276.444J
KCF data

ATOM        30
            1   N4y N    28.8231  -16.7197
            2   C8y C    29.2429  -18.0488
            3   C8y C    29.9424  -15.8802
            4   C1b C    27.5639  -16.0201
            5   N5x N    30.6420  -18.0488
            6   C1b C    28.4034  -19.1681
            7   C8y C    31.0617  -16.7197
            8   C1b C    29.9424  -14.4811
            9   C8y C    26.3747  -16.7896
            10  C1b C    28.9630  -20.4273
            11  X   Cl   32.3909  -16.2999
            12  O1a O    31.1317  -13.7815
            13  C8x C    26.3747  -18.1887
            14  C8x C    25.1854  -16.0901
            15  C1b C    28.1935  -21.5466
            16  C8x C    25.1854  -18.8883
            17  C8x C    23.9962  -16.8596
            18  C1a C    28.7532  -22.8758
            19  C8y C    23.9962  -18.1887
            20  C8y C    22.7369  -18.8883
            21  C8y C    21.5477  -18.2587
            22  C8x C    22.7370  -20.2874
            23  C8y C    21.5477  -16.8596
            24  C8x C    20.3585  -18.9583
            25  C8x C    21.6177  -20.9870
            26  N4x N    20.4284  -16.0201
            27  N5x N    22.7370  -16.0201
            28  C8x C    20.3585  -20.3573
            29  N5x N    20.8482  -14.6910
            30  N5x N    22.2473  -14.6910
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12    9  13 2
            13    9  14 1
            14   10  15 1
            15   13  16 1
            16   14  17 2
            17   15  18 1
            18   16  19 2
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 1
            23   21  24 2
            24   22  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   27  30 1
            30    5   7 1
            31   17  19 1
            32   25  28 2
            33   29  30 2

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