| Entry |
|
|---|
| Name |
Midodrine (INN) |
|---|
| Formula |
C12H18N2O4
|
|---|
| Exact mass |
254.1267
|
|---|
| Mol weight |
254.2823
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
| Product (DG00224): | D01307<JP/US> |
|
|---|
| Efficacy |
Antihypotensive, alpha1-Adrenergic receptor agonist |
|---|
| Comment |
Phenethylamine derivative
Active form of prodrug: Deglymidodrine [CPD: C21521]
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
C01CA Adrenergic and dopaminergic agents
C01CA17 Midodrine
D08220 Midodrine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG00224 Midodrine
D08220 Midodrine
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG00224 Midodrine
D08220 Midodrine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00224 Midodrine
D08220 Midodrine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D08220 Midodrine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08220
Prodrugs [br08324.html]
D08220
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01702 Phenethylamine cardiotonic
DG00224 Midodrine
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG00224 Midodrine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00224 Midodrine
Prodrugs [br08324.html]
DG00224
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 18
1 C8y C 14.0000 -20.5100
2 C8x C 14.0000 -21.9100
3 C8x C 15.2124 -22.6100
4 C8y C 16.4249 -21.9100
5 C8y C 16.4249 -20.5100
6 C8x C 15.2124 -19.8100
7 C1c C 17.6560 -19.7990
8 C1b C 18.8612 -20.4947
9 O1a O 17.6557 -18.4101
10 N1b N 20.0435 -19.8119
11 C5a C 21.2375 -20.5012
12 C1b C 22.4254 -19.8152
13 N1a N 23.6165 -20.5029
14 O5a O 21.2377 -21.9097
15 O2a O 12.7876 -19.8100
16 C1a C 11.5921 -20.5004
17 O2a O 17.6560 -22.6210
18 C1a C 17.6560 -24.0210
BOND 18
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 1
9 7 9 1
10 8 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 11 14 2
15 1 15 1
16 15 16 1
17 4 17 1
18 17 18 1
|
|---|
