| Entry |
|
|---|
| Name |
Mometasone (INN) |
|---|
| Formula |
C22H28Cl2O4
|
|---|
| Exact mass |
426.1365
|
|---|
| Mol weight |
427.3613
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00419): | D00690<JP/US> D03325<JP/US> |
|
|---|
| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC13 Mometasone
D08227 Mometasone (INN)
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XC Corticosteroids, potent, other combinations
D07XC03 Mometasone
D08227 Mometasone (INN)
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD09 Mometasone
D08227 Mometasone (INN)
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
R03BA Glucocorticoids
R03BA07 Mometasone
D08227 Mometasone (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00419 Mometasone
D08227 Mometasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00419 Mometasone
D08227 Mometasone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D08227 Mometasone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08227
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00419 Mometasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00419 Mometasone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C1z C 23.5200 -18.7600
2 C1y C 24.7100 -19.3900
3 C1z C 22.3300 -19.3900
4 C1y C 23.5200 -17.3600
5 X Cl 23.5200 -20.0900
6 C1y C 25.9000 -18.7600
7 C1x C 24.7100 -20.7900
8 C2y C 22.3300 -20.7900
9 C2x C 21.1400 -18.7600
10 C1a C 22.3300 -18.0600
11 C1x C 24.7100 -16.7300
12 O1a O 22.3300 -16.6600
13 C1z C 25.9000 -17.3600
14 C1x C 28.2100 -18.7600
15 C1x C 23.5200 -21.4900
16 C2x C 21.1400 -21.4900
17 C2x C 20.0200 -19.3900
18 C1z C 27.0200 -16.7300
19 C1a C 25.9000 -16.0300
20 C1y C 28.2100 -17.3600
21 C5x C 20.0200 -20.7900
22 C5a C 27.0200 -15.1200
23 O1a O 28.2100 -16.0300
24 C1a C 29.5400 -16.9400
25 O5x O 18.8300 -21.4200
26 C1b C 28.2100 -14.4200
27 O5a O 25.8300 -14.4200
28 X Cl 29.4000 -15.1200
BOND 31
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Down
5 2 6 1
6 2 7 1
7 3 8 1
8 3 9 1
9 3 10 1 #Up
10 4 11 1
11 4 12 1 #Up
12 6 13 1
13 6 14 1
14 7 15 1
15 8 16 2
16 9 17 2
17 13 18 1
18 13 19 1 #Up
19 14 20 1
20 16 21 1
21 18 22 1 #Up
22 18 23 1 #Down
23 20 24 1 #Down
24 21 25 2
25 22 26 1
26 22 27 2
27 26 28 1
28 8 15 1
29 11 13 1
30 17 21 1
31 18 20 1
|
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