KEGG DRUG: Naloxone

DRUG: Naloxone

Entry

D08249                      Drug

Name

Naloxone (INN);
DBL Naloxone (TN)

Formula

C19H21NO4

Exact mass

327.1471

Mol weight

327.3743

Structure

Simcomp

Class

Analgesic
DG01586 Opioid receptor antagonist

Remark

Same as:

C07252

ATC code:

A06AH04 V03AB15

Chemical structure group:

DG01155

Product (DG01155):

D01340<JP/US> D11620<US>

Product (mixture):

D10250<US>

Efficacy

Narcotic antagonist, Respiratory stimulant, Opioid receptor antagonist

Comment

Normorphine derivative

Target

OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa05032

Morphine addiction

Structure map

map07039

Opioid analgesics

map07224

Opioid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AH Peripheral opioid receptor antagonists
     A06AH04 Naloxone
      D08249  Naloxone (INN)
V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB15 Naloxone
      D08249  Naloxone (INN)
Drug groups [BR:br08330]
Analgesic
  DG01586  Opioid receptor antagonist
   DG01155  Naloxone
    D08249  Naloxone
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08249  Naloxone (INN)
    OPRK1
     D08249  Naloxone (INN)
    OPRD1
     D08249  Naloxone (INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D08249
Drug groups [BR:br08330]
Analgesic
  DG01586  Opioid receptor antagonist
   DG01155  Naloxone

Other DBs

CAS:

465-65-6

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        24
            1   C1z C    21.9100  -18.6200
            2   C8y C    21.9100  -17.2900
            3   C1z C    23.1000  -19.2500
            4   C1y C    20.7900  -19.1800
            5   C1x C    23.1000  -17.9900
            6   C8y C    20.7900  -16.6600
            7   C8y C    23.1000  -16.6600
            8   C1y C    24.2200  -18.6200
            9   C1x C    23.1000  -20.5100
            10  O2x O    19.4600  -17.9200
            11  C5x C    20.7900  -20.5100
            12  C1x C    25.3400  -17.9900
            13  C8y C    20.7900  -15.3300
            14  C1x C    24.2200  -17.3600
            15  C8x C    23.1000  -15.3300
            16  N1y N    25.3400  -19.2500
            17  C1x C    21.9100  -21.2100
            18  O5x O    19.6700  -21.2100
            19  C8x C    21.9800  -14.7000
            20  O1a O    19.6700  -14.7000
            21  O1a O    24.3600  -20.1600
            22  C1b C    26.7400  -19.2500
            23  C2b C    27.4400  -20.5100
            24  C2a C    28.8400  -20.5100
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15    8  16 1 #Up
            16    9  17 1
            17   11  18 2
            18   13  19 2
            19   13  20 1
            20    6  10 1
            21    8  14 1
            22   11  17 1
            23   12  16 1
            24   15  19 1
            25    3  21 1 #Up
            26   16  22 1
            27   22  23 1
            28   23  24 2

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