| Entry |
|
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| Name |
Naratriptan (INN);
Naramig (TN) |
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| Formula |
C17H25N3O2S
|
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| Exact mass |
335.1667
|
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| Mol weight |
335.4643
|
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| Structure |
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| Simcomp |
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| Class |
|
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| Remark |
| Product (DG00837): | D00674<JP/US> |
|
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| Efficacy |
Antimigraine, Vasoconstrictor, Serotonin receptor agonist |
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| Comment |
Sumatriptan derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2C9 [HSA: 1559], CYP2D6 [HSA: 1565], CYP2E1 [HSA: 1571], CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]
|
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02C ANTIMIGRAINE PREPARATIONS
N02CC Selective serotonin (5HT1) agonists
N02CC02 Naratriptan
D08255 Naratriptan (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01483 5-HT1A-receptor agonist
DG00837 Naratriptan
D08255 Naratriptan
Analgesic
DG01484 5-HT1B-receptor agonist
DG00837 Naratriptan
D08255 Naratriptan
DG01485 5-HT1D-receptor agonist
DG00837 Naratriptan
D08255 Naratriptan
DG01518 5-HT1B/1D-receptor agonist
DG00837 Naratriptan
D08255 Naratriptan
DG01943 Triptan
DG00837 Naratriptan
D08255 Naratriptan
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00837 Naratriptan
D08255 Naratriptan
DG01642 CYP2C9 substrate
DG00837 Naratriptan
D08255 Naratriptan
DG01644 CYP2D6 substrate
DG00837 Naratriptan
D08255 Naratriptan
DG02855 CYP2E1 substrate
DG00837 Naratriptan
D08255 Naratriptan
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00837 Naratriptan
D08255 Naratriptan
DG02925 CYP3A5 substrate
DG00837 Naratriptan
D08255 Naratriptan
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1B
D08255 Naratriptan (INN)
HTR1D
D08255 Naratriptan (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08255
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01483 5-HT1A-receptor agonist
DG00837 Naratriptan
Analgesic
DG01484 5-HT1B-receptor agonist
DG00837 Naratriptan
DG01485 5-HT1D-receptor agonist
DG00837 Naratriptan
DG01518 5-HT1B/1D-receptor agonist
DG00837 Naratriptan
DG01943 Triptan
DG00837 Naratriptan
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00837 Naratriptan
DG01642 CYP2C9 substrate
DG00837 Naratriptan
DG01644 CYP2D6 substrate
DG00837 Naratriptan
DG02855 CYP2E1 substrate
DG00837 Naratriptan
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00837 Naratriptan
DG02925 CYP3A5 substrate
DG00837 Naratriptan
|
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| Other DBs |
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| KCF data |
ATOM 23
1 C8y C 27.1600 -19.9500
2 C8y C 28.4900 -19.4600
3 C8y C 27.1600 -21.3500
4 C8x C 25.9000 -19.2500
5 C8x C 29.3300 -20.6500
6 N4x N 28.4900 -21.7700
7 C8x C 25.9000 -22.0500
8 C8y C 24.7100 -19.9500
9 C8x C 24.7100 -21.3500
10 C1b C 23.5200 -19.2500
11 C1b C 22.3300 -19.9500
12 S4a S 21.0700 -19.2500
13 N1b N 19.8800 -19.9500
14 O3c O 22.3300 -18.5500
15 O3c O 19.8800 -18.5500
16 C1a C 18.6900 -19.2500
17 C1y C 28.4900 -18.0600
18 C1x C 29.6800 -17.3600
19 C1x C 29.6800 -15.9600
20 N1y N 28.4900 -15.2600
21 C1x C 27.3000 -15.9600
22 C1x C 27.3000 -17.3600
23 C1a C 28.4900 -13.8600
BOND 25
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 3 6 1
6 3 7 1
7 4 8 2
8 7 9 2
9 8 10 1
10 10 11 1
11 11 12 1
12 12 13 1
13 12 14 2
14 12 15 2
15 13 16 1
16 5 6 1
17 8 9 1
18 2 17 1
19 17 18 1
20 18 19 1
21 19 20 1
22 20 21 1
23 21 22 1
24 17 22 1
25 20 23 1
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