| Entry |
|
|---|
| Name |
Nicardipine (INN);
Cardene (TN) |
|---|
| Formula |
C26H29N3O6
|
|---|
| Exact mass |
479.2056
|
|---|
| Mol weight |
479.525
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00323): | D00617<JP/US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA04 Nicardipine
D08270 Nicardipine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00323 Nicardipine
D08270 Nicardipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00323 Nicardipine
D08270 Nicardipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00323 Nicardipine
D08270 Nicardipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D08270 Nicardipine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08270
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00323 Nicardipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00323 Nicardipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00323 Nicardipine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 35
1 C1y C 20.5800 -16.3800
2 C8y C 20.5800 -17.7800
3 C2y C 21.7700 -15.6800
4 C2y C 19.3900 -15.6800
5 C8x C 21.8400 -18.4800
6 C8x C 19.3900 -18.4800
7 C2y C 21.7700 -14.3500
8 C7a C 23.0300 -16.3800
9 C2y C 19.3900 -14.3500
10 C7a C 18.2000 -16.3800
11 C8y C 21.8400 -19.8100
12 C8x C 19.3900 -19.8800
13 N1x N 20.5800 -13.6500
14 C1a C 23.0300 -13.6500
15 O7a O 24.2200 -15.6800
16 O6a O 23.0300 -17.7800
17 C1a C 18.2000 -13.6500
18 O7a O 17.0100 -15.6800
19 O6a O 18.2000 -17.7800
20 C8x C 20.6500 -20.5100
21 N2b N 23.0300 -20.5100 #+
22 C1b C 25.4100 -16.3800
23 C1a C 15.8200 -16.3800
24 O3a O 24.5000 -19.6000
25 O3a O 23.0300 -22.2600 #-
26 C1b C 26.6000 -15.6800
27 N1c N 27.7900 -16.3800
28 C1b C 28.9800 -15.6800
29 C1a C 27.7900 -17.7800
30 C8y C 30.1700 -16.3800
31 C8x C 30.1700 -17.7800
32 C8x C 31.3600 -15.6800
33 C8x C 31.3600 -18.4800
34 C8x C 32.5500 -16.3800
35 C8x C 32.5500 -17.7800
BOND 37
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 2
11 6 12 1
12 7 13 1
13 7 14 1
14 8 15 1
15 8 16 2
16 9 17 1
17 10 18 1
18 10 19 2
19 11 20 1
20 11 21 1
21 15 22 1
22 18 23 1
23 21 24 2
24 21 25 1
25 22 26 1
26 26 27 1
27 27 28 1
28 27 29 1
29 28 30 1
30 30 31 2
31 30 32 1
32 31 33 1
33 32 34 2
34 33 35 2
35 9 13 1
36 12 20 2
37 34 35 1
|
|---|
