| Entry |
|
|---|
| Name |
Nortriptyline (INN);
Nortrilen (TN) |
|---|
| Formula |
C19H21N
|
|---|
| Exact mass |
263.1674
|
|---|
| Mol weight |
263.3767
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00935): | D00816<JP/US> |
|
|---|
| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA10 Nortriptyline
D08288 Nortriptyline (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00935 Nortriptyline
D08288 Nortriptyline
DG01728 Tricyclic antidepressant
DG00935 Nortriptyline
D08288 Nortriptyline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00935 Nortriptyline
D08288 Nortriptyline
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D08288 Nortriptyline (INN)
SLC6A4 (HTT)
D08288 Nortriptyline (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08288
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00935 Nortriptyline
DG01728 Tricyclic antidepressant
DG00935 Nortriptyline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00935 Nortriptyline
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 20
1 C1x C 22.9600 -20.5100
2 C8y C 22.0500 -19.3900
3 C8y C 22.4000 -17.9900
4 C2y C 23.6600 -17.4300
5 C1x C 24.4300 -20.5100
6 C8y C 24.9900 -18.0600
7 C8y C 25.2700 -19.3900
8 C8x C 21.4200 -17.0100
9 C8x C 20.0900 -17.4300
10 C8x C 19.7400 -18.7600
11 C8x C 20.7200 -19.7400
12 C8x C 26.6000 -19.8800
13 C8x C 27.6500 -18.9000
14 C8x C 27.3700 -17.5700
15 C8x C 26.0400 -17.1500
16 C2b C 23.6600 -16.0300
17 C1b C 24.9200 -15.4000
18 C1b C 26.1100 -16.1000
19 N1b N 27.3000 -15.4000
20 C1a C 28.5600 -16.1000
BOND 22
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
|
|---|
