| Entry |
|
|---|
| Name |
Olopatadine (INN) |
|---|
| Formula |
C21H23NO3
|
|---|
| Exact mass |
337.1678
|
|---|
| Mol weight |
337.4122
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Remark |
| Product (DG01039): | D01192<JP/US> |
| Product (mixture): | D12501<US> |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Comment |
Loratadine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AC Antiallergic agents, excl. corticosteroids
R01AC08 Olopatadine
D08293 Olopatadine (INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01G DECONGESTANTS AND ANTIALLERGICS
S01GX Other antiallergics
S01GX09 Olopatadine
D08293 Olopatadine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01039 Olopatadine
D08293 Olopatadine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D08293 Olopatadine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01039 Olopatadine
|
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| Other DBs |
|
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| KCF data |
ATOM 25
1 O2x O 19.4571 -20.5498
2 C8y C 18.6155 -19.4276
3 C8y C 18.8961 -18.0250
4 C2y C 20.1585 -17.4639
5 C1x C 20.8598 -20.5498
6 C8y C 21.4209 -18.0951
7 C8y C 21.7014 -19.4978
8 C8x C 17.9141 -17.0430
9 C8y C 16.5816 -17.4639
10 C8x C 16.2309 -18.7965
11 C8x C 17.2128 -19.7783
12 C8x C 23.1041 -19.9185
13 C8x C 24.0860 -18.9367
14 C8x C 23.8054 -17.6041
15 C8x C 22.4729 -17.1834
16 C2b C 20.1585 -16.0612
17 C1b C 15.5295 -16.4821
18 C6a C 14.1970 -16.9028
19 O6a O 13.2151 -15.9210
20 O6a O 13.8464 -18.2354
21 C1b C 18.9665 -15.3438
22 C1b C 18.9665 -13.9446
23 N1c N 17.7547 -13.2450
24 C1a C 16.5641 -13.9322
25 C1a C 17.7546 -11.8241
BOND 27
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 4 16 2
19 9 17 1
20 17 18 1
21 18 19 1
22 18 20 2
23 16 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 23 25 1
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