| Entry |
|
|---|
| Name |
Oxymetazoline (INN);
Operil (TN) |
|---|
| Formula |
C16H24N2O
|
|---|
| Exact mass |
260.1889
|
|---|
| Mol weight |
260.3746
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
|
|---|
| Remark |
| Product (DG01029): | D01022<US> |
|
|---|
| Efficacy |
Vasoconstrictor, alpha1-Adrenergic receptor agonist |
|---|
| Comment |
Imidazoline derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D11 OTHER DERMATOLOGICAL PREPARATIONS
D11A OTHER DERMATOLOGICAL PREPARATIONS
D11AX Other dermatologicals
D11AX27 Oxymetazoline
D08322 Oxymetazoline (INN)
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AA Sympathomimetics, plain
R01AA05 Oxymetazoline
D08322 Oxymetazoline (INN)
R01AB Sympathomimetics, combinations excl. corticosteroids
R01AB07 Oxymetazoline
D08322 Oxymetazoline (INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01G DECONGESTANTS AND ANTIALLERGICS
S01GA Sympathomimetics used as decongestants
S01GA04 Oxymetazoline
D08322 Oxymetazoline (INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Oxymetazoline
D08322 Oxymetazoline (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01029 Oxymetazoline
D08322 Oxymetazoline
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1A
D08322 Oxymetazoline (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01029 Oxymetazoline
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 C8y C 19.3900 -16.5900
2 C8y C 19.3900 -17.9900
3 C8y C 20.5800 -18.6900
4 C8x C 21.7700 -17.9900
5 C8y C 21.7700 -16.5900
6 C8y C 20.5800 -15.8900
7 C1b C 20.5800 -14.4200
8 C2y C 21.7700 -13.7200
9 N1x N 23.1000 -14.1400
10 C1x C 23.8700 -13.0900
11 C1x C 23.1000 -11.9700
12 N2x N 21.7700 -12.3900
13 C1a C 23.0300 -15.8200
14 C1a C 18.1300 -15.8900
15 O1a O 18.1300 -18.6900
16 C1d C 20.5800 -20.0900
17 C1a C 21.9800 -20.0900
18 C1a C 19.1800 -20.0900
19 C1a C 20.5800 -21.4900
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 8 12 2
14 5 13 1
15 1 14 1
16 2 15 1
17 3 16 1
18 16 17 1
19 16 18 1
20 16 19 1
|
|---|
