| Entry |
|
|---|
| Name |
Phenylpropanolamine (INN);
Fansia (TN) |
|---|
| Formula |
C9H13NO
|
|---|
| Exact mass |
151.0997
|
|---|
| Mol weight |
151.2056
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Vasoconstrictor, Adrenergic receptor agonist |
|---|
| Comment |
Relative configuration (racemic mixture)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
CYP inhibition: CYP1A2 [HSA: 1544]
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01B NASAL DECONGESTANTS FOR SYSTEMIC USE
R01BA Sympathomimetics
R01BA01 Phenylpropanolamine
D08368 Phenylpropanolamine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01041 Phenylpropanolamine
D08368 Phenylpropanolamine
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG01041 Phenylpropanolamine
D08368 Phenylpropanolamine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D08368 Phenylpropanolamine (INN)
ADRA2
D08368 Phenylpropanolamine (INN)
ADRB
D08368 Phenylpropanolamine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08368
Narcotics and psychotropics in Japan [br08308.html]
Stimulants by Control Act Article 2 Appended Table and Cabinet Order
D08368
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01041 Phenylpropanolamine
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG01041 Phenylpropanolamine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 11
1 C8x C 15.6269 -16.2060
2 C8x C 15.6269 -17.6076
3 C8x C 16.8407 -18.3084
4 C8x C 18.0546 -17.6076
5 C8y C 18.0546 -16.2060
6 C8x C 16.8407 -15.5052
7 C1c C 19.2871 -15.4941
8 C1c C 20.4937 -16.1906
9 O1a O 19.2868 -14.1037
10 N1a N 21.6773 -15.5071
11 C1a C 20.4941 -17.6072
BOND 11
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 5 1
8 7 8 1
9 7 9 1 #Up
10 8 10 1
11 8 11 1 #Up
|
|---|
