| Entry |
|
|---|
| Name |
Pioglitazone (INN);
Actos (TN) |
|---|
| Formula |
C19H20N2O3S
|
|---|
| Exact mass |
356.1195
|
|---|
| Mol weight |
356.4387
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
| Product (DG00117): | D00945<JP/US> |
| Product (mixture): | D09744<JP/US> D09848<JP/US> |
|
|---|
| Efficacy |
Antidiabetic, Peroxisome proliferator-activated receptor (PPAR) gamma agonist |
|---|
| Comment |
Thiazolidinedione derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C8 [HSA: 1558]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07222 | Peroxisome proliferator-activated receptor (PPAR) agonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BG Thiazolidinediones
A10BG03 Pioglitazone
D08378 Pioglitazone (INN)
Drug groups [BR:br08330]
Antidiabetic agent
DG01685 Insulin sensitizer
DG01795 PPAR gamma agonist
DG01683 Thiazolidinedione
DG00117 Pioglitazone
D08378 Pioglitazone
DG02044 Hypoglycemic agent
DG01683 Thiazolidinedione
DG00117 Pioglitazone
D08378 Pioglitazone
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00117 Pioglitazone
D08378 Pioglitazone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Peroxisome proliferator-activated receptor (PPAR)
NR1C3 (PPARG)
D08378 Pioglitazone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08378
Drug groups [BR:br08330]
Antidiabetic agent
DG01685 Insulin sensitizer
DG01795 PPAR gamma agonist
DG01683 Thiazolidinedione
DG00117 Pioglitazone
DG02044 Hypoglycemic agent
DG01683 Thiazolidinedione
DG00117 Pioglitazone
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00117 Pioglitazone
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 25
1 C1y C 32.9700 -20.3700
2 C1b C 31.7800 -19.6700
3 C8y C 30.5900 -20.3700
4 C8x C 29.3300 -19.6700
5 C8x C 30.5900 -21.7700
6 C8x C 28.1400 -20.3700
7 C8x C 29.3300 -22.4700
8 C8y C 28.1400 -21.7700
9 O2a O 26.9500 -22.4700
10 C1b C 25.6900 -21.7700
11 C1b C 24.5700 -22.4700
12 C8y C 23.3800 -21.7700
13 C8x C 23.3800 -20.3700
14 N5x N 22.1900 -22.4700
15 C8x C 22.1900 -19.6700
16 C8x C 20.9300 -21.7700
17 C8y C 20.9300 -20.3700
18 C1b C 19.7400 -19.6700
19 C1a C 18.5500 -20.3700
20 C5x C 32.9698 -21.7700
21 N1x N 34.3013 -22.2028
22 C5x C 35.1243 -21.0703
23 S2x S 34.3015 -19.9375
24 O5x O 36.5400 -21.0704
25 O5x O 31.8372 -22.5927
BOND 27
1 1 2 1
2 2 3 1
3 3 4 2
4 3 5 1
5 4 6 1
6 5 7 2
7 6 8 2
8 8 9 1
9 9 10 1
10 10 11 1
11 11 12 1
12 12 13 2
13 12 14 1
14 13 15 1
15 14 16 2
16 15 17 2
17 17 18 1
18 18 19 1
19 7 8 1
20 16 17 1
21 1 20 1
22 20 21 1
23 21 22 1
24 22 23 1
25 1 23 1
26 22 24 2
27 20 25 2
|
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