| Entry |
|
|---|
| Name |
Prazosin (INN);
Minipress (TN) |
|---|
| Formula |
C19H21N5O4
|
|---|
| Exact mass |
383.1594
|
|---|
| Mol weight |
383.4011
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG01739 Peripherally-acting antiadrenergic
DG03231 Antihypertensive
Transporter inhibitor
DG02881 SLC22A3 inhibitor
|
|---|
| Remark |
| Product (DG00253): | D00609<JP/US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator (peripheric), alpha1-Adrenergic receptor antagonist |
|---|
| Comment |
Prazosin derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
Transporter inhibition: SLC22A3 [HSA: 6581]
|
|---|
| Structure map |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
|
|---|
| Other map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
C02CA Alpha-adrenoreceptor antagonists
C02CA01 Prazosin
D08411 Prazosin (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00253 Prazosin
D08411 Prazosin
DG01739 Peripherally-acting antiadrenergic
DG00253 Prazosin
D08411 Prazosin
DG03231 Antihypertensive
DG00253 Prazosin
D08411 Prazosin
Transporter inhibitor
DG02881 SLC22A3 inhibitor
DG00253 Prazosin
D08411 Prazosin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D08411 Prazosin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D08411
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
DG00253 Prazosin
DG01739 Peripherally-acting antiadrenergic
DG00253 Prazosin
DG03231 Antihypertensive
DG00253 Prazosin
Transporter inhibitor
DG02881 SLC22A3 inhibitor
DG00253 Prazosin
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C8y C 27.1600 -19.6700
2 C8y C 27.1600 -18.2700
3 C8x C 28.3500 -20.3700
4 C8y C 25.9000 -20.3700
5 N5x N 25.9000 -17.5700
6 C8x C 28.3500 -17.5700
7 C8y C 29.5400 -19.6700
8 N5x N 24.7100 -19.6700
9 N1a N 25.9000 -21.7700
10 C8y C 24.7100 -18.2700
11 C8y C 29.5400 -18.2700
12 O2a O 30.8000 -20.3700
13 N1y N 23.5200 -17.5700
14 O2a O 30.8000 -17.5700
15 C1a C 31.9900 -19.6700
16 C1x C 23.5200 -16.2400
17 C1x C 22.2600 -18.2700
18 C1a C 31.9900 -18.2700
19 C1x C 22.2600 -15.4700
20 C1x C 21.0700 -17.5700
21 N1y N 21.0700 -16.2400
22 C5a C 19.8800 -15.4700
23 C8y C 18.6200 -16.2400
24 O5a O 19.8800 -14.0700
25 C8x C 18.2700 -17.5700
26 O2x O 17.5000 -15.4000
27 C8x C 16.8700 -17.5700
28 C8x C 16.3800 -16.3100
BOND 31
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 4 9 1
9 5 10 2
10 6 11 2
11 7 12 1
12 10 13 1
13 11 14 1
14 12 15 1
15 13 16 1
16 13 17 1
17 14 18 1
18 16 19 1
19 17 20 1
20 19 21 1
21 21 22 1
22 22 23 1
23 22 24 2
24 23 25 2
25 23 26 1
26 25 27 1
27 26 28 1
28 7 11 1
29 8 10 1
30 20 21 1
31 27 28 2
|
|---|
