| Entry |
|
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| Name |
Propafenone (INN);
Propafenon hexal (TN) |
|---|
| Formula |
C21H27NO3
|
|---|
| Exact mass |
341.1991
|
|---|
| Mol weight |
341.444
|
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00200): | D00640<JP/US> |
|
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| Efficacy |
Antiarrhythmic, Sodium channel blocker |
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576], CYP1A2 [HSA: 1544]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01B ANTIARRHYTHMICS, CLASS I AND III
C01BC Antiarrhythmics, class Ic
C01BC03 Propafenone
D08435 Propafenone (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
DG00200 Propafenone
D08435 Propafenone
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00200 Propafenone
D08435 Propafenone
DG01644 CYP2D6 substrate
DG00200 Propafenone
D08435 Propafenone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00200 Propafenone
D08435 Propafenone
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D08435 Propafenone (INN)
SCN2A
D08435 Propafenone (INN)
SCN3A
D08435 Propafenone (INN)
SCN4A
D08435 Propafenone (INN)
SCN5A
D08435 Propafenone (INN)
SCN8A
D08435 Propafenone (INN)
SCN9A
D08435 Propafenone (INN)
SCN10A
D08435 Propafenone (INN)
SCN11A
D08435 Propafenone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08435
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
DG00200 Propafenone
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00200 Propafenone
DG01644 CYP2D6 substrate
DG00200 Propafenone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00200 Propafenone
|
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| Other DBs |
|
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| KCF data |
ATOM 25
1 C8y C 27.2300 -18.2700
2 C8y C 27.2300 -19.6700
3 O2a O 25.9700 -17.5700
4 C8x C 28.4200 -17.5700
5 C5a C 25.9700 -20.3700
6 C8x C 28.4200 -20.3700
7 C1b C 25.9700 -16.1700
8 C8x C 29.6100 -18.2700
9 C1b C 24.7800 -19.6700
10 O5a O 25.9700 -21.7700
11 C8x C 29.6100 -19.6700
12 C1c C 24.7800 -15.4700
13 C1b C 23.5900 -20.4400
14 C1b C 23.5900 -16.1700
15 O1a O 24.7800 -14.0700
16 C8y C 22.4000 -19.7400
17 N1b N 22.4000 -15.4700
18 C8x C 22.4000 -18.3400
19 C8x C 21.1400 -20.4400
20 C1b C 21.1400 -16.2400
21 C8x C 21.1400 -17.6400
22 C8x C 19.9500 -19.7400
23 C1b C 19.9500 -15.5400
24 C8x C 19.9500 -18.3400
25 C1a C 18.7600 -16.2400
BOND 26
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 1
7 4 8 1
8 5 9 1
9 5 10 2
10 6 11 1
11 7 12 1
12 9 13 1
13 12 14 1
14 12 15 1
15 13 16 1
16 14 17 1
17 16 18 2
18 16 19 1
19 17 20 1
20 18 21 1
21 19 22 2
22 20 23 1
23 21 24 2
24 23 25 1
25 8 11 2
26 22 24 1
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