KEGG DRUG: Quinidine

DRUG: Quinidine

Entry

D08458                      Drug

Name

Quinidine (BAN);
Kinidin (TN)

Formula

C20H24N2O2

Exact mass

324.1838

Mol weight

324.4168

Structure

Simcomp

Source

Cinchona calisaya [TAX:153742], Cinchona succirubra, Cinchona calisaya

Class

Cardiovascular agent
DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent

Remark

Same as:

C06527

ATC code:

C01BA01

Chemical structure group:

DG00192

Product (DG00192):

D00642<US> D02272<JP/US>

Efficacy

Antiarrhythmic, Antimalarial, Sodium channel blocker

Comment

Cinchona lkaloid

Target

SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]

Pathway

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04728

Dopaminergic synapse

Interaction

Structure map

map07025

Quinolines

map07037

Antiarrhythmic drugs

map07231

Sodium channel blocking drugs

Other map

map04976

Bile secretion

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA01 Quinidine
      D08458  Quinidine (BAN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00192  Quinidine
      D08458  Quinidine
Target-based classification of drugs [BR:br08310]
Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D08458  Quinidine (BAN)
    SCN2A
     D08458  Quinidine (BAN)
    SCN3A
     D08458  Quinidine (BAN)
    SCN4A
     D08458  Quinidine (BAN)
    SCN5A
     D08458  Quinidine (BAN)
    SCN8A
     D08458  Quinidine (BAN)
    SCN9A
     D08458  Quinidine (BAN)
    SCN10A
     D08458  Quinidine (BAN)
    SCN11A
     D08458  Quinidine (BAN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01649  Class Ia antiarrhythmic agent
     DG00192  Quinidine

Other DBs

CAS:

56-54-2

PubChem:

96025144

ChEBI:

182417 28593

PDB-CCD:

QDN[PDBj]

LigandBox:

D08458

NIKKAJI:

J4.570E

KCF data

ATOM        24
            1   C8y C    25.2071  -26.8235
            2   C8y C    26.4637  -26.1254
            3   C8y C    25.2071  -28.2197
            4   C8x C    24.0203  -26.1254
            5   C1c C    26.4637  -24.7292
            6   C8x C    27.6505  -26.8235
            7   C8x C    24.0203  -28.9178
            8   N5x N    26.3939  -28.9178
            9   C8y C    22.7637  -26.8235
            10  C1y C    27.6505  -24.0311
            11  O1a O    25.2071  -24.0311
            12  C8x C    27.6505  -28.2197
            13  C8x C    22.7637  -28.2197
            14  O2a O    21.5769  -26.1254
            15  N1y N    29.1165  -23.1235
            16  C1x C    26.9524  -22.9839
            17  C1a C    21.5769  -24.7292
            18  C1x C    29.1165  -21.8669
            19  C1x C    30.5825  -23.9613
            20  C1y C    28.3486  -22.1462
            21  C1y C    28.3486  -21.1688
            22  C1x C    29.8844  -22.8443
            23  C2b C    27.7901  -19.8424
            24  C2a C    28.6976  -18.7254
BOND        27
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 1 #Down
            11    6  12 1
            12    7  13 2
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   14  17 1
            17   15  18 1
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   19  22 1
            22   21  23 1 #Up
            23   23  24 2
            24    8  12 2
            25    9  13 1
            26   20  21 1
            27   20  22 1

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