| Entry |
|
|---|
| Name |
Rabeprazole (INN);
Eraloc (TN) |
|---|
| Formula |
C18H21N3O3S
|
|---|
| Exact mass |
359.1304
|
|---|
| Mol weight |
359.4426
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00022): | D00724<JP/US> |
| Product (mixture): | D10519<JP> |
|
|---|
| Efficacy |
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor |
|---|
| Comment |
Benzimidazole derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC04 Rabeprazole
D08463 Rabeprazole (INN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00022 Rabeprazole
D08463 Rabeprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00022 Rabeprazole
D08463 Rabeprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00022 Rabeprazole
D08463 Rabeprazole
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D08463 Rabeprazole (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08463
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00022 Rabeprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00022 Rabeprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00022 Rabeprazole
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 25
1 C8x C 16.8700 -17.6400
2 C8x C 16.8700 -19.0400
3 C8x C 18.0600 -19.7400
4 C8y C 19.2500 -19.0400
5 C8y C 19.2500 -17.6400
6 C8x C 18.0600 -16.9400
7 N5x N 20.5800 -19.4600
8 C8y C 21.4200 -18.3400
9 N4x N 20.5800 -17.2200
10 S4a S 22.8200 -18.3400
11 C1b C 23.5200 -19.6000
12 O3c O 23.5200 -17.1500
13 C8y C 24.9200 -19.6000
14 C8y C 25.6200 -20.7900
15 C8y C 27.0200 -20.7900
16 C8x C 27.7200 -19.5300
17 C8x C 27.0200 -18.3400
18 N5x N 25.6200 -18.3400
19 C1a C 24.9200 -21.9800
20 O2a O 27.7200 -21.9800
21 C1b C 29.1200 -21.9800
22 C1b C 29.8200 -23.1700
23 C1b C 31.2200 -23.1700
24 O2a O 31.9200 -24.3600
25 C1a C 33.3200 -24.3600
BOND 27
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 5 9 1
11 8 10 1
12 10 11 1
13 10 12 2
14 11 13 1
15 13 14 2
16 14 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 13 18 1
21 14 19 1
22 15 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 24 25 1
|
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