| Entry |
|
|---|
| Name |
Rasagiline (USAN/INN);
Azilect (TN) |
|---|
| Formula |
C12H13N
|
|---|
| Exact mass |
171.1048
|
|---|
| Mol weight |
171.2383
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01512 Monoamine oxidase B inhibitor
DG01967 Antiparkinson agent
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
|
|---|
| Remark |
| Product (DG00865): | D02562<JP/US> |
|
|---|
| Efficacy |
Antiparkinsonian, Neuroprotectant, Monoamine oxidase B (MAO-B) inhibitor |
|---|
| Comment |
Treatment of Parkinson's disease
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07216 | Catecholamine transferase inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N04 ANTI-PARKINSON DRUGS
N04B DOPAMINERGIC AGENTS
N04BD Monoamine oxidase B inhibitors
N04BD02 Rasagiline
D08469 Rasagiline (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01512 Monoamine oxidase B inhibitor
DG00865 Rasagiline
D08469 Rasagiline
DG01967 Antiparkinson agent
DG00865 Rasagiline
D08469 Rasagiline
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00865 Rasagiline
D08469 Rasagiline
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Amine oxidases
MAOB
D08469 Rasagiline (USAN/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D08469
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08469
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01512 Monoamine oxidase B inhibitor
DG00865 Rasagiline
DG01967 Antiparkinson agent
DG00865 Rasagiline
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00865 Rasagiline
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 13
1 C8y C 22.8900 -17.7100
2 C8y C 22.8900 -16.3100
3 C8x C 21.7000 -15.6100
4 C8x C 20.5100 -16.3100
5 C8x C 20.5100 -17.7100
6 C8x C 21.7000 -18.4100
7 C1y C 24.2200 -18.1300
8 C1x C 25.0600 -17.0100
9 C1x C 24.2200 -15.8200
10 N1b N 24.2200 -19.5300
11 C1b C 25.4800 -20.2300
12 C3b C 26.6700 -19.5300
13 C3a C 27.8600 -18.8300
BOND 14
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 7 8 1
9 8 9 1
10 2 9 1
11 7 10 1 #Up
12 10 11 1
13 11 12 1
14 12 13 3
|
|---|
