| Entry |
|
|---|
| Name |
Ropivacaine (INN);
Naropin (TN) |
|---|
| Formula |
C17H26N2O
|
|---|
| Exact mass |
274.2045
|
|---|
| Mol weight |
274.4011
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00806): | D04048<JP/US> |
|
|---|
| Efficacy |
Anesthetic (local) |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N01 ANESTHETICS
N01B ANESTHETICS, LOCAL
N01BB Amides
N01BB09 Ropivacaine
D08490 Ropivacaine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
DG00806 Ropivacaine
D08490 Ropivacaine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00806 Ropivacaine
D08490 Ropivacaine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00806 Ropivacaine
D08490 Ropivacaine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D08490 Ropivacaine (INN)
SCN2A
D08490 Ropivacaine (INN)
SCN3A
D08490 Ropivacaine (INN)
SCN4A
D08490 Ropivacaine (INN)
SCN5A
D08490 Ropivacaine (INN)
SCN8A
D08490 Ropivacaine (INN)
SCN9A
D08490 Ropivacaine (INN)
SCN10A
D08490 Ropivacaine (INN)
SCN11A
D08490 Ropivacaine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08490
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
DG00806 Ropivacaine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00806 Ropivacaine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00806 Ropivacaine
|
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| Other DBs |
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| KCF data |
ATOM 20
1 C1y C 26.9298 -19.4988
2 N1y N 26.9298 -20.8966
3 C5a C 25.7416 -18.7999
4 C1x C 28.1878 -18.7999
5 C1x C 28.1178 -21.6653
6 C1b C 25.6718 -21.5954
7 N1b N 24.4836 -19.4988
8 O5a O 25.7421 -17.6817
9 C1x C 29.3758 -19.4988
10 C1x C 29.3754 -20.9665
11 C8y C 23.2956 -18.6602
12 C8y C 22.0376 -19.3590
13 C8y C 23.2956 -17.2624
14 C8x C 20.7795 -18.6602
15 C1a C 22.0376 -20.6869
16 C8x C 22.0376 -16.5634
17 C1a C 24.4836 -16.5634
18 C8x C 20.7795 -17.2624
19 C1b C 24.4938 -20.9026
20 C1a C 23.2688 -21.5965
BOND 21
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 1
9 5 10 1
10 7 11 1
11 11 12 2
12 11 13 1
13 12 14 1
14 12 15 1
15 13 16 2
16 13 17 1
17 14 18 2
18 9 10 1
19 16 18 1
20 6 19 1
21 19 20 1
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