KEGG   DRUG: Sibutramine
Entry
D08513                      Drug                                   
Name
Sibutramine (INN);
Butramin (TN)
Formula
C17H26ClN
Exact mass
279.1754
Mol weight
279.848
Structure
Simcomp
Class
Gastrointestinal agent
 DG01705  Anoretic
  DG01704  Phenethylamine anorexic
Remark
Same as: C07247
ATC code: A08AA10
Chemical structure group: DG00108
Efficacy
Appetite suppressant, Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
Comment
Serotonin norepinephrine reuptake inhibitor (SNRI)
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07027  Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA10 Sibutramine
      D08513  Sibutramine (INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG00108  Sibutramine
     D08513  Sibutramine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08513  Sibutramine (INN)
    SLC6A3 (DAT1)
     D08513  Sibutramine (INN)
    SLC6A4 (HTT)
     D08513  Sibutramine (INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG00108  Sibutramine
Other DBs
CAS: 106650-56-0
PubChem: 96025198
ChEBI: 9137
LigandBox: D08513
NIKKAJI: J247.963J
KCF data

ATOM        19
            1   C1z C    16.3100  -20.3700
            2   C8y C    15.1200  -21.0700
            3   C1c C    17.5000  -21.0700
            4   C1x C    17.2900  -19.3900
            5   C1x C    15.3300  -19.3900
            6   C8x C    15.1200  -22.4700
            7   C8x C    13.8600  -20.3700
            8   N1c N    18.7600  -20.3700
            9   C1x C    16.3100  -18.4100
            10  C8x C    13.8600  -23.1700
            11  C8x C    12.6000  -21.0700
            12  C1a C    19.9500  -21.0700
            13  C8y C    12.6000  -22.4700
            14  X   Cl   11.4100  -23.1700
            15  C1a C    18.7772  -18.9701
            16  C1b C    17.4828  -22.4699
            17  C1c C    18.6992  -23.1924
            18  C1a C    19.9226  -22.5061
            19  C1a C    18.6820  -24.5700
BOND        20
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 2
            10    7  11 1
            11    8  12 1
            12   10  13 1
            13   13  14 1
            14    5   9 1
            15   11  13 2
            16    8  15 1
            17    3  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

» Japanese version   » Back

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (5)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
Gene (6)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (3)   
All databases (18)   

Download RDF
DBGET integrated database retrieval system