| Entry |
|
|---|
| Name |
Ticlopidine (INN);
Ticlopidin-Puren (TN) |
|---|
| Formula |
C14H14ClNS
|
|---|
| Exact mass |
263.0535
|
|---|
| Mol weight |
263.7857
|
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| Structure |
|
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| Simcomp |
|
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| Class |
|
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| Remark |
| Product (DG00156): | D01028<JP> |
|
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| Efficacy |
Anticoagulant, Platelet aggregation inhibitor, Purinergic receptor P2Y12 antagonist |
|---|
| Comment |
Thienopyridine derivative
|
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| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP2C19 [HSA: 1557], CYP1A2 [HSA: 1544], CYP2B6 [HSA: 1555], CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AC Platelet aggregation inhibitors excl. heparin
B01AC05 Ticlopidine
D08594 Ticlopidine (INN)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01808 Thienopyridine
DG00156 Ticlopidine
D08594 Ticlopidine
DG01809 P2Y12 receptor antagonist
DG01808 Thienopyridine
DG00156 Ticlopidine
D08594 Ticlopidine
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG00156 Ticlopidine
D08594 Ticlopidine
DG02892 CYP2B6 inhibitor
DG00156 Ticlopidine
D08594 Ticlopidine
DG01933 CYP2C19 inhibitor
DG00156 Ticlopidine
D08594 Ticlopidine
DG01645 CYP2D6 inhibitor
DG00156 Ticlopidine
D08594 Ticlopidine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Purine / pyrimidine
P2RY12
D08594 Ticlopidine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08594
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG01808 Thienopyridine
DG00156 Ticlopidine
DG01809 P2Y12 receptor antagonist
DG01808 Thienopyridine
DG00156 Ticlopidine
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG00156 Ticlopidine
DG02892 CYP2B6 inhibitor
DG00156 Ticlopidine
DG01933 CYP2C19 inhibitor
DG00156 Ticlopidine
DG01645 CYP2D6 inhibitor
DG00156 Ticlopidine
|
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| Other DBs |
|
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| KCF data |
ATOM 17
1 C8x C 19.4600 -17.2200
2 C8x C 19.4600 -18.6200
3 C8x C 20.6500 -19.3200
4 C8y C 21.9100 -18.6200
5 C8y C 21.9100 -17.2200
6 C8x C 20.6500 -16.5200
7 C1b C 23.1000 -19.3200
8 N1y N 24.2900 -18.6200
9 C1x C 24.2900 -17.2200
10 X Cl 23.1000 -16.5200
11 C1x C 25.5500 -19.3200
12 C8y C 26.7400 -18.6200
13 C8y C 26.7400 -17.2200
14 C1x C 25.5500 -16.5200
15 C8x C 28.0700 -19.0400
16 C8x C 28.9100 -17.9200
17 S2x S 28.0700 -16.8000
BOND 19
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 5 10 1
11 8 11 1
12 11 12 1
13 12 13 2
14 13 14 1
15 9 14 1
16 12 15 1
17 15 16 2
18 16 17 1
19 13 17 1
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