| Entry |
|
|---|
| Name |
Trazodone (INN);
Trittico (TN) |
|---|
| Formula |
C19H22ClN5O
|
|---|
| Exact mass |
371.1513
|
|---|
| Mol weight |
371.8639
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG03056 Serotonin antagonist and reuptake inhibitor (SARI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00952): | D00820<JP/US> |
|
|---|
| Efficacy |
Tranquilizer, Antidepressant, Serotonin antagonist and reuptake inhibitor (SARI) |
|---|
| Comment |
triazolopyridines
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX05 Trazodone
D08626 Trazodone (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03056 Serotonin antagonist and reuptake inhibitor (SARI)
DG00952 Trazodone
D08626 Trazodone
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00952 Trazodone
D08626 Trazodone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00952 Trazodone
D08626 Trazodone
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR2
D08626 Trazodone (INN)
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D08626 Trazodone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08626
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03056 Serotonin antagonist and reuptake inhibitor (SARI)
DG00952 Trazodone
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00952 Trazodone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00952 Trazodone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 26
1 N4y N 17.8500 -18.4800
2 C1b C 19.0400 -19.1800
3 C1b C 20.2300 -18.5500
4 C1b C 21.4200 -19.2500
5 N1y N 22.6800 -18.5500
6 C1x C 22.6800 -17.1500
7 C1x C 23.8700 -19.2500
8 C1x C 23.8700 -16.3800
9 C1x C 25.1300 -18.5500
10 N1y N 25.1300 -17.1500
11 C8y C 26.3200 -16.3800
12 C8x C 26.3200 -14.9800
13 C8x C 27.5100 -17.1500
14 C8y C 27.5100 -14.2800
15 C8x C 28.7700 -16.3800
16 C8x C 28.7700 -14.9800
17 X Cl 27.5100 -12.8800
18 N5x N 17.5000 -17.0800
19 C8y C 16.1000 -17.0800
20 N4y N 15.6100 -18.4100
21 C8y C 16.7300 -19.2500
22 O5x O 16.7300 -20.5800
23 C8x C 15.1200 -16.0300
24 C8x C 13.7900 -16.3100
25 C8x C 13.3000 -17.6400
26 C8x C 14.2800 -18.6900
BOND 29
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 5 7 1
7 6 8 1
8 7 9 1
9 8 10 1
10 10 11 1
11 11 12 1
12 11 13 2
13 12 14 2
14 13 15 1
15 14 16 1
16 14 17 1
17 9 10 1
18 15 16 2
19 1 18 1
20 18 19 2
21 19 20 1
22 20 21 1
23 1 21 1
24 21 22 2
25 19 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 20 26 1
|
|---|
