| Entry |
|
|---|
| Name |
Trifluoperazine (INN);
Apo-trifluoperazine (TN) |
|---|
| Formula |
C21H24F3N3S
|
|---|
| Exact mass |
407.1643
|
|---|
| Mol weight |
407.4956
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
|
|---|
| Remark |
| Product (DG00877): | D00799<US> |
|
|---|
| Efficacy |
Antipsychotic, Neuroleptic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB06 Trifluoperazine
D08636 Trifluoperazine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00877 Trifluoperazine
D08636 Trifluoperazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00877 Trifluoperazine
D08636 Trifluoperazine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D08636 Trifluoperazine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00877 Trifluoperazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00877 Trifluoperazine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C8y C 21.7000 -20.3700
2 N1y N 22.8900 -19.6700
3 C8y C 21.7000 -21.7700
4 C8x C 20.5100 -19.6700
5 C8y C 24.1500 -20.4400
6 C1b C 22.8900 -18.2700
7 S2x S 22.8900 -22.4700
8 C8x C 20.5100 -22.4700
9 C8x C 19.2500 -20.4400
10 C8y C 24.1500 -21.7700
11 C8x C 25.3400 -19.7400
12 C1b C 24.1500 -17.5700
13 C8x C 19.2500 -21.7700
14 C8x C 25.3400 -22.4700
15 C8y C 26.6000 -20.4400
16 C1b C 24.1500 -16.1700
17 C8x C 26.6000 -21.7700
18 N1y N 25.3400 -15.4700
19 C1x C 25.4100 -14.0700
20 C1x C 26.6000 -16.1700
21 C1x C 26.6000 -13.3700
22 C1x C 27.8600 -15.4700
23 N1y N 27.8600 -14.0700
24 C1a C 29.0500 -13.3700
25 C1d C 27.7900 -19.7400
26 X F 28.9800 -19.0400
27 X F 28.4900 -20.9300
28 X F 27.0900 -18.5500
BOND 31
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 2
10 5 11 1
11 6 12 1
12 8 13 2
13 10 14 1
14 11 15 2
15 12 16 1
16 14 17 2
17 16 18 1
18 18 19 1
19 18 20 1
20 19 21 1
21 20 22 1
22 21 23 1
23 23 24 1
24 7 10 1
25 9 13 1
26 15 17 1
27 22 23 1
28 15 25 1
29 25 26 1
30 25 27 1
31 25 28 1
|
|---|
