| Entry |
|
|---|
| Name |
Tripelennamine (INN) |
|---|
| Formula |
C16H21N3
|
|---|
| Exact mass |
255.1735
|
|---|
| Mol weight |
255.358
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Comment |
Phenbenzamine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA04 Tripelennamine
D08645 Tripelennamine (INN)
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AC Substituted ethylene diamines
R06AC04 Tripelennamine
D08645 Tripelennamine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00383 Tripelennamine
D08645 Tripelennamine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00383 Tripelennamine
D08645 Tripelennamine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D08645 Tripelennamine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08645
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00383 Tripelennamine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00383 Tripelennamine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 C8x C 19.3200 -16.9400
2 C8x C 19.3200 -18.3400
3 C8x C 20.5800 -19.0400
4 C8x C 21.7700 -18.3400
5 C8y C 21.7700 -16.9400
6 C8x C 20.5800 -16.2400
7 N5x N 22.9600 -19.0400
8 C8y C 24.2200 -18.3400
9 N1c N 24.2200 -16.9400
10 C1b C 22.9600 -16.2400
11 C8x C 22.9600 -20.4400
12 C8x C 24.2200 -21.1400
13 C8x C 25.4100 -20.4400
14 C8x C 25.4100 -19.0400
15 C1b C 25.4100 -16.2400
16 C1b C 26.6000 -16.8700
17 N1c N 27.7900 -16.2400
18 C1a C 28.9800 -16.8700
19 C1a C 27.7900 -14.7700
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 9 10 1
10 5 10 1
11 7 11 2
12 11 12 1
13 12 13 2
14 13 14 1
15 8 14 2
16 9 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 17 19 1
|
|---|
