| Entry |
|
|---|
| Name |
Vardenafil (USAN/INN);
Levitra (TN) |
|---|
| Formula |
C23H32N6O4S
|
|---|
| Exact mass |
488.2206
|
|---|
| Mol weight |
488.603
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00487): | D03260<JP/US> |
|
|---|
| Efficacy |
Vasodilator, Impotence therapy, Phosphodiesterase V inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BE Drugs used in erectile dysfunction
G04BE09 Vardenafil
D08668 Vardenafil (USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
DG00487 Vardenafil
D08668 Vardenafil
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00487 Vardenafil
D08668 Vardenafil
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Phosphodiesterases
PDE5
D08668 Vardenafil (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08668
Drug groups [BR:br08330]
Cardiovascular agent
DG01509 Phosphodiesterase V inhibitor
DG00487 Vardenafil
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00487 Vardenafil
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 34
1 C8y C 25.4100 -18.6900
2 C8y C 26.6000 -17.9900
3 C8y C 25.4100 -20.0900
4 C8x C 24.1500 -17.9900
5 N4x N 27.7900 -18.6900
6 N5x N 26.6000 -16.5900
7 C8x C 24.1500 -20.7900
8 O2a O 26.6000 -20.7900
9 C8y C 22.9600 -18.6900
10 N4y N 29.0500 -17.9900
11 C8y C 27.7900 -15.8900
12 C8x C 22.9600 -20.0900
13 C1b C 27.7900 -20.0900
14 S4a S 21.7700 -17.9900
15 C8y C 29.0500 -16.5900
16 C8y C 30.3800 -18.4100
17 O5x O 27.7900 -14.4900
18 C1a C 28.9800 -20.7900
19 N1y N 20.5800 -18.6900
20 O3c O 22.7500 -17.0100
21 O3c O 20.7900 -17.0100
22 C8y C 30.3800 -16.1700
23 N5x N 31.2200 -17.2900
24 C1b C 30.8000 -19.7400
25 C1x C 20.5800 -20.0900
26 C1x C 19.3200 -17.9900
27 C1a C 30.8000 -14.8400
28 C1b C 32.1300 -20.0200
29 C1x C 19.3200 -20.7900
30 C1x C 18.1300 -18.6900
31 C1a C 32.5500 -21.3500
32 N1y N 18.1300 -20.0900
33 C1b C 16.9400 -20.7900
34 C1a C 15.7500 -20.0900
BOND 37
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 2 6 2
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 9 14 1
14 10 15 1
15 10 16 1
16 11 17 2
17 13 18 1
18 14 19 1
19 14 20 2
20 14 21 2
21 15 22 2
22 16 23 2
23 16 24 1
24 19 25 1
25 19 26 1
26 22 27 1
27 24 28 1
28 25 29 1
29 26 30 1
30 28 31 1
31 29 32 1
32 32 33 1
33 9 12 2
34 11 15 1
35 22 23 1
36 30 32 1
37 33 34 1
|
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