KEGG   DRUG: Vinorelbine
Entry
D08680                      Drug                                   
Name
Vinorelbine (INN);
Navelbine (TN)
Formula
C45H54N4O8
Exact mass
778.3942
Mol weight
778.9323
Structure
Simcomp
Class
Antineoplastic
 DG01965  Vinca alkaloid antineoplastic
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: L01CA04
Chemical structure group: DG00692
Product (DG00692): D01935<JP/US>
Efficacy
Antineoplastic, Tubulin polymerization inhibitor
Comment
Semisynthetic vinblastine derivative
Target
  Pathway
hsa04540  Gap junction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07042  Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
    L01CA Vinca alkaloids and analogues
     L01CA04 Vinorelbine
      D08680  Vinorelbine (INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01965  Vinca alkaloid antineoplastic
   DG00692  Vinorelbine
    D08680  Vinorelbine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00692  Vinorelbine
     D08680  Vinorelbine
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    TUBB
     D08680  Vinorelbine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08680
Drug groups [BR:br08330]
 Antineoplastic
  DG01965  Vinca alkaloid antineoplastic
   DG00692  Vinorelbine
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00692  Vinorelbine
Other DBs
CAS: 71486-22-1
PubChem: 96025363
ChEBI: 480999
LigandBox: D08680
NIKKAJI: J328.171J
KCF data

ATOM        57
            1   C1z C    27.0900  -27.5100
            2   C8y C    25.9700  -26.7400
            3   C1x C    28.3500  -26.7400
            4   C7a C    26.7400  -28.7700
            5   C8y C    25.9700  -25.3400
            6   N4x N    24.8500  -27.3700
            7   C1y C    28.3500  -25.4800
            8   O7a O    25.2700  -29.2600
            9   O6a O    27.5800  -29.8200
            10  C8y C    23.6600  -25.3400
            11  C8y C    23.6600  -26.7400
            12  C1x C    27.2300  -24.8500
            13  C1a C    24.4300  -30.6600
            14  C8x C    22.4700  -24.7100
            15  C8x C    22.4700  -27.3700
            16  N1y N    27.2300  -23.5900
            17  C8x C    21.4200  -25.3400
            18  C8x C    21.4200  -26.7400
            19  C1x C    28.3500  -22.8200
            20  C2y C    29.4700  -23.4500
            21  C2x C    29.4700  -24.6400
            22  C1b C    30.7300  -22.7500
            23  C1a C    31.9200  -23.4500
            24  C1x C    25.9700  -23.9400
            25  C1z C    34.6500  -29.6800
            26  C1y C    35.7700  -28.9800
            27  C1y C    34.6500  -30.9400
            28  C1x C    33.8100  -28.5600
            29  C1z C    36.8900  -29.6800
            30  N1y N    35.7700  -27.6500
            31  C1z C    35.7700  -31.6400
            32  N1y N    33.5300  -31.6400
            33  C8y C    32.4100  -30.9400
            34  C1x C    34.4400  -27.6500
            35  C1y C    36.8900  -30.9400
            36  C2x C    38.0800  -28.9800
            37  C1b C    38.0100  -30.3100
            38  C1x C    36.8900  -27.0200
            39  C7a C    36.6800  -32.7600
            40  O1a O    35.2800  -33.5300
            41  C1a C    33.5300  -32.9700
            42  O7a O    40.2500  -32.2700
            43  C2x C    38.0800  -27.6500
            44  C1a C    39.1300  -29.6800
            45  O7a O    36.6800  -34.0900
            46  O6a O    38.0100  -32.2700
            47  C1a C    37.8700  -34.7900
            48  C1a C    42.7000  -32.2700
            49  C7a C    41.4400  -31.5700
            50  O6a O    41.4400  -30.1700
            51  C8y C    32.4100  -29.6800
            52  C8x C    31.2900  -29.0500
            53  C8x C    31.2900  -31.6400
            54  C8y C    30.1700  -29.6800
            55  C8y C    30.1700  -31.0100
            56  O2a O    29.0500  -31.6400
            57  C1a C    27.9300  -31.0100
BOND        65
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    7  12 1
            12    7  21 1
            13    8  13 1
            14   10  14 1
            15   11  15 1
            16   16  12 1
            17   14  17 2
            18   15  18 2
            19   16  19 1
            20   10  11 2
            21   20  19 1
            22   17  18 1
            23   20  21 2
            24   20  22 1
            25   22  23 1
            26    5  24 1
            27   16  24 1 #Up
            28   25  26 1
            29   25  27 1
            30   25  28 1 #Up
            31   26  29 1
            32   26  30 1
            33   27  31 1
            34   27  32 1
            35   28  34 1
            36   29  35 1
            37   29  36 1
            38   29  37 1 #Down
            39   30  38 1
            40   31  39 1 #Down
            41   31  40 1 #Up
            42   32  41 1
            43   35  42 1 #Up
            44   36  43 2
            45   37  44 1
            46   39  45 1
            47   30  34 1
            48   31  35 1
            49   32  33 1
            50   38  43 1
            51   39  46 2
            52   45  47 1
            53   48  49 1
            54   42  49 1
            55   49  50 2
            56   51  52 1
            57   33  53 1
            58   52  54 2
            59   53  55 2
            60   55  56 1
            61   56  57 1
            62   54  55 1
            63   51  25 1
            64   51  33 2
            65    1  54 1 #Down

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