| Entry |
|
|---|
| Name |
Zolpidem (INN);
Sanval (TN) |
|---|
| Formula |
C19H21N3O
|
|---|
| Exact mass |
307.1685
|
|---|
| Mol weight |
307.3895
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01836 Non-benzodiazepine sedative-hypnotics
DG03202 Hypnotic
DG01567 GABA-A receptor agonist
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01642 CYP2C9 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00922): | D00706<JP/US> |
|
|---|
| Efficacy |
Sedative-hypnotic |
|---|
| Comment |
Imidazopyridines
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2C9 [HSA: 1559], CYP1A2 [HSA: 1544]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05C HYPNOTICS AND SEDATIVES
N05CF Benzodiazepine related drugs
N05CF02 Zolpidem
D08690 Zolpidem (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01836 Non-benzodiazepine sedative-hypnotics
DG00922 Zolpidem
D08690 Zolpidem
DG03202 Hypnotic
DG00922 Zolpidem
D08690 Zolpidem
DG01567 GABA-A receptor agonist
DG00922 Zolpidem
D08690 Zolpidem
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00922 Zolpidem
D08690 Zolpidem
DG01642 CYP2C9 substrate
DG00922 Zolpidem
D08690 Zolpidem
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00922 Zolpidem
D08690 Zolpidem
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D08690 Zolpidem (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08690
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D08690
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01836 Non-benzodiazepine sedative-hypnotics
DG00922 Zolpidem
DG03202 Hypnotic
DG00922 Zolpidem
DG01567 GABA-A receptor agonist
DG00922 Zolpidem
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00922 Zolpidem
DG01642 CYP2C9 substrate
DG00922 Zolpidem
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00922 Zolpidem
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 23
1 C8y C 23.4500 -17.1500
2 C8y C 24.2900 -16.0300
3 N4y N 22.1200 -16.6600
4 C1b C 23.4500 -18.5500
5 C8y C 25.6900 -16.0300
6 N5x N 23.4500 -14.8400
7 C8y C 22.1200 -15.2600
8 C8x C 20.9300 -17.3600
9 C5a C 24.6400 -19.1800
10 C8x C 26.3900 -17.2200
11 C8x C 26.3900 -14.7700
12 C8x C 20.9300 -14.5600
13 C8y C 19.6700 -16.6600
14 N1c N 24.6400 -20.5800
15 O5a O 25.9000 -18.4800
16 C8x C 27.7900 -17.2200
17 C8x C 27.7900 -14.7700
18 C8x C 19.6700 -15.2600
19 C1a C 18.4800 -17.3600
20 C1a C 25.9000 -21.2800
21 C1a C 23.4500 -21.2800
22 C8y C 28.4900 -16.0300
23 C1a C 29.8900 -16.0300
BOND 25
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 1
9 5 10 2
10 5 11 1
11 7 12 1
12 8 13 2
13 9 14 1
14 9 15 2
15 10 16 1
16 11 17 2
17 12 18 2
18 13 19 1
19 14 20 1
20 14 21 1
21 16 22 2
22 22 23 1
23 6 7 2
24 13 18 1
25 17 22 1
|
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