KEGG   DRUG: Azilsartan
Entry
D08864                      Drug                                   
Name
Azilsartan (JAN/USAN/INN);
Azilva (TN)
Formula
C25H20N4O5
Exact mass
456.1434
Mol weight
456.4501
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
 DG03231  Antihypertensive
  DG01495  Angiotensin II receptor antagonist
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 2149
Chemical structure group: DG00351
Product (DG00351): D08864<JP> D08865<US>
Product (mixture): D10524<JP>
Efficacy
Antihypertensive, Angiotensin II receptor antagonist
Comment
Treatment of hypertension
Target
AGTR1 [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Brite
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Azilsartan
    D08864  Azilsartan (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D08864  Azilsartan (JAN/USAN/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01495  Angiotensin II receptor antagonist
    DG00351  Azilsartan
     D08864  Azilsartan
  DG03231  Antihypertensive
   DG01495  Angiotensin II receptor antagonist
    DG00351  Azilsartan
     D08864  Azilsartan
 Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D08864  Azilsartan
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01495  Angiotensin II receptor antagonist
   D08864  Azilsartan
  DG03231  Antihypertensive
   D08864  Azilsartan
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D08864  Azilsartan (JAN/USAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D08864
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08864
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08864
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01495  Angiotensin II receptor antagonist
    DG00351  Azilsartan
  DG03231  Antihypertensive
   DG01495  Angiotensin II receptor antagonist
    DG00351  Azilsartan
Other DBs
CAS: 147403-03-0
PubChem: 96025547
ChEBI: 68850
LigandBox: D08864
KCF data

ATOM        34
            1   C8y C    22.2302  -17.2042
            2   N4y N    21.8107  -15.8755
            3   C8y C    23.6288  -17.2042
            4   C8y C    21.5309  -18.3929
            5   C8y C    22.9295  -15.0364
            6   C1b C    20.6219  -15.1762
            7   N5x N    24.1183  -15.8755
            8   C8x C    24.3281  -18.3929
            9   C8x C    22.2302  -19.5817
            10  C6a C    20.8317  -19.5817
            11  O2a O    22.9295  -13.6378
            12  C8y C    19.3632  -15.8755
            13  C8x C    23.6288  -19.5817
            14  O6a O    21.5309  -20.8404
            15  C1b C    24.1882  -12.9385
            16  C8x C    18.1744  -15.2461
            17  C8x C    19.3631  -17.2741
            18  C1a C    24.1882  -11.5399
            19  C8x C    16.9856  -15.9454
            20  C8x C    18.2443  -18.0433
            21  C8y C    16.9856  -17.3440
            22  C8y C    15.7968  -18.0433
            23  C8y C    14.5381  -17.4139
            24  C8x C    15.7968  -19.4419
            25  C8y C    14.5381  -15.9454
            26  C8x C    13.4193  -18.1132
            27  C8x C    14.6080  -20.2111
            28  N4x N    13.4192  -15.1762
            29  N5x N    15.6569  -15.1063
            30  C8x C    13.4192  -19.5118
            31  C8y C    13.8388  -13.8476
            32  O7x O    15.2374  -13.8476
            33  O6a O    12.9842  -12.7405
            34  O6a O    19.4332  -19.5645
BOND        38
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    8  13 2
            13   10  14 2
            14   11  15 1
            15   12  16 1
            16   12  17 2
            17   15  18 1
            18   16  19 2
            19   17  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 1
            25   23  26 2
            26   24  27 1
            27   25  28 1
            28   25  29 2
            29   26  30 1
            30   28  31 1
            31   29  32 1
            32    5   7 2
            33    9  13 1
            34   20  21 2
            35   27  30 2
            36   31  32 1
            37   31  33 2
            38   10  34 1

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Chemical substance (2)   
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