KEGG   DRUG: Betrixaban
Entry
D08873                      Drug                                   
Name
Betrixaban (USAN);
Bevyxxa (TN)
Formula
C23H22ClN5O3
Exact mass
451.1411
Mol weight
451.9055
Structure
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01662  Factor Xa inhibitor
Remark
ATC code: B01AF04
Efficacy
Antithrombotic, Factor Xa inhibitor
Comment
Prevention of deep vein thrombosis and pulmonary embolism after surgery
Target
F10 [HSA:2159] [KO:K01314]
  Pathway
hsa04610  Complement and coagulation cascades
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AF Direct factor Xa inhibitors
     B01AF04 Betrixaban
      D08873  Betrixaban (USAN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01662  Factor Xa inhibitor
    D08873  Betrixaban
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Serine peptidases
    F10
     D08873  Betrixaban (USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08873
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08873
Other DBs
CAS: 330942-05-7
PubChem: 96025556
ChEBI: 140421
LigandBox: D08873
KCF data

ATOM        32
            1   C8y C    15.6800  -12.5300
            2   C8x C    15.6800  -13.9300
            3   C8x C    16.8700  -14.6300
            4   C8y C    18.0600  -13.9300
            5   C8x C    18.0600  -12.5300
            6   C8x C    16.8700  -11.9000
            7   C2c C    14.4200  -11.9000
            8   N1c N    13.2300  -12.5300
            9   C5a C    19.2500  -14.6300
            10  N2a N    14.4200  -10.5000
            11  N1b N    20.4400  -14.0000
            12  C8y C    21.6300  -14.6300
            13  O5a O    19.2500  -16.0300
            14  C1a C    12.0441  -11.7860
            15  C1a C    13.2486  -13.9291
            16  C8x C    21.6114  -16.0291
            17  C8x C    22.9187  -16.6841
            18  C8y C    24.1046  -15.9401
            19  C8x C    24.0532  -14.5410
            20  C8y C    22.8159  -13.8860
            21  O2a O    25.3305  -16.5894
            22  C1a C    26.5231  -15.8415
            23  C5a C    22.8335  -12.4611
            24  O5a O    21.5152  -11.8003
            25  N1b N    23.9402  -11.7228
            26  C8y C    25.1637  -12.3700
            27  C8x C    25.1467  -13.7873
            28  C8x C    26.4544  -14.4416
            29  C8y C    27.5699  -13.6968
            30  C8x C    27.5869  -12.2795
            31  N5x N    26.3492  -11.6253
            32  X   Cl   28.8181  -14.3736
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     4   9 1
            10    7  10 2
            11    9  11 1
            12   11  12 1
            13    9  13 2
            14    8  14 1
            15    8  15 1
            16   12  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   12  20 1
            22   18  21 1
            23   21  22 1
            24   20  23 1
            25   23  24 2
            26   23  25 1
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   29  30 1
            32   30  31 2
            33   26  31 1
            34   29  32 1

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Ontology (5)   
   KEGG BRITE (5)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (11)   

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