KEGG   DRUG: Carfilzomib
Entry
D08880                      Drug                                   
Name
Carfilzomib (JAN/USAN/INN);
Kyprolis (TN)
Product
KYPROLIS (Onyx Pharmaceuticals)
Formula
C40H57N5O7
Exact mass
719.4258
Mol weight
719.9099
Structure
Class
Antineoplastic
 DG03134  Proteasome inhibitor
Remark
Therapeutic category: 4291
ATC code: L01XG02
Product: D08880<JP/US>
Efficacy
Antineoplastic, Proteasome inhibitor
  Disease
Multiple myeloma [DS:H00010]
Target
PSMB5 [HSA:5693] [KO:K02737]
  Pathway
hsa03050  Proteasome
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XG Proteasome inhibitors
     L01XG02 Carfilzomib
      D08880  Carfilzomib (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Carfilzomib
    D08880  Carfilzomib (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D08880  Carfilzomib (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG03134  Proteasome inhibitor
   D08880  Carfilzomib
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Threonine peptidases
    PSMB5
     D08880  Carfilzomib (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08880
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08880
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D08880
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08880
Other DBs
CAS: 868540-17-4
PubChem: 96025563
ChEBI: 65347
LigandBox: D08880
NIKKAJI: J2.711.864J
KCF data

ATOM        52
            1   C1b C    11.3830  -17.9082
            2   C5a C    12.5990  -17.2061
            3   N1b N    13.8151  -17.9082
            4   C1c C    15.0311  -17.2061
            5   C5a C    16.2471  -17.9082
            6   N1b N    17.4632  -17.2061
            7   C1c C    18.6793  -17.9082
            8   C5a C    19.8953  -17.2061
            9   N1b N    21.1114  -17.9082
            10  C1c C    22.3274  -17.2061
            11  C5a C    23.5435  -17.9082
            12  N1b N    24.7595  -17.2061
            13  C1c C    25.9755  -17.9082
            14  C5a C    27.1917  -17.2061
            15  N1y N    10.1670  -17.2061
            16  C1z C    28.3193  -17.8990
            17  C1x C    10.1670  -15.8022
            18  C1x C     8.9510  -15.1001
            19  O2x O     7.7348  -15.8020
            20  C1x C     7.7348  -17.2061
            21  C1x C     8.9510  -17.9082
            22  O5a O    27.1409  -15.8023
            23  O5a O    23.5435  -19.3123
            24  O5a O    19.8953  -15.8020
            25  O5a O    16.2471  -19.3123
            26  O5a O    12.5990  -15.8022
            27  C1b C    22.3274  -15.8019
            28  C1b C    15.0311  -15.8019
            29  C1b C    25.9755  -19.3124
            30  C1b C    18.6793  -19.3124
            31  O2x O    29.5378  -17.2392
            32  C1x C    29.5353  -18.6011
            33  C8y C    23.5495  -15.0964
            34  C1b C    16.2492  -15.0987
            35  C8y C    16.2492  -13.6945
            36  C8x C    17.4483  -13.0020
            37  C8x C    17.4481  -11.5979
            38  C8x C    16.2320  -10.8960
            39  C8x C    15.0330  -11.5883
            40  C8x C    15.0331  -12.9925
            41  C8x C    24.7516  -15.7905
            42  C8x C    25.9677  -15.0886
            43  C8x C    25.9679  -13.6845
            44  C8x C    24.7658  -12.9902
            45  C8x C    23.5497  -13.6922
            46  C1c C    19.8953  -20.0145
            47  C1a C    21.0984  -19.3197
            48  C1a C    19.8953  -21.4185
            49  C1c C    27.1916  -20.0145
            50  C1a C    28.3988  -19.3174
            51  C1a C    27.1917  -21.4186
            52  C1a C    28.3193  -16.4948
BOND        55
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    1  15 1
            15   14  16 1
            16   15  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   15  21 1
            22   14  22 2
            23   11  23 2
            24    8  24 2
            25    5  25 2
            26    2  26 2
            27   10  27 1 #Up
            28    4  28 1 #Up
            29   13  29 1 #Down
            30    7  30 1 #Down
            31   16  31 1
            32   16  32 1
            33   31  32 1
            34   27  33 1
            35   28  34 1
            36   34  35 1
            37   35  36 2
            38   36  37 1
            39   37  38 2
            40   38  39 1
            41   39  40 2
            42   35  40 1
            43   33  41 2
            44   41  42 1
            45   42  43 2
            46   43  44 1
            47   44  45 2
            48   33  45 1
            49   30  46 1
            50   46  47 1
            51   46  48 1
            52   29  49 1
            53   49  50 1
            54   49  51 1
            55   16  52 1 #Up

» Japanese version   » Back

  All links  
Ontology (9)   
   KEGG BRITE (9)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (17)   

Download RDF
DBGET integrated database retrieval system