| Entry |
|
|---|
| Name |
Perampanel (USAN);
Fycompa (TN) |
|---|
| Formula |
C23H15N3O
|
|---|
| Exact mass |
349.1215
|
|---|
| Mol weight |
349.3847
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG01569 AMPA receptor antagonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
|---|
| Remark |
| Product (DG01901): | D10780<JP/US> |
|
|---|
| Efficacy |
Antiepileptic, AMPA receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX22 Perampanel
D08964 Perampanel (USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG01569 AMPA receptor antagonist
DG01901 Perampanel
D08964 Perampanel
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01901 Perampanel
D08964 Perampanel
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), non-NMDA
GRIA
D08964 Perampanel (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08964
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG01569 AMPA receptor antagonist
DG01901 Perampanel
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG01901 Perampanel
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 27
1 C8x C 15.7500 -15.1200
2 C8x C 15.7500 -16.5200
3 C8y C 16.9624 -17.2200
4 C8y C 18.1749 -16.5200
5 C8x C 18.1749 -15.1200
6 C8x C 16.9624 -14.4200
7 C8y C 19.4060 -17.2310
8 C8x C 19.4057 -18.6199
9 C8y C 20.6180 -19.3202
10 C8x C 21.8306 -18.6205
11 N4y N 21.8309 -17.2316
12 C8y C 20.6186 -16.5313
13 C3b C 16.9624 -18.6198
14 N3a N 16.9624 -20.0198
15 C8y C 23.0553 -16.5251
16 C8x C 24.2463 -17.2133
17 C8x C 25.4590 -16.5137
18 C8x C 25.4595 -15.1137
19 C8x C 24.2686 -14.4255
20 C8x C 23.0559 -15.1251
21 C8y C 20.6177 -20.7196
22 N5x N 19.4294 -21.4057
23 C8x C 19.4294 -22.8057
24 C8x C 20.6419 -23.5057
25 C8x C 21.8301 -22.8196
26 C8x C 21.8301 -21.4196
27 O5x O 20.6187 -15.1204
BOND 30
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 1
13 7 12 1
14 3 13 1
15 13 14 3
16 11 15 1
17 15 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 15 20 1
23 9 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 21 26 1
30 12 27 2
|
|---|
