KEGG   DRUG: Favipiravir
Entry
D09537                      Drug                                   
Name
Favipiravir (JAN/USAN/INN);
Avigan (TN)
  Abbr
FPV
Formula
C5H4FN3O2
Exact mass
157.0288
Mol weight
157.1026
Structure
Class
Antiviral
 DG03029  Anti-influenza virus agent
Metabolizing enzyme substrate
 DG02953  AOX1 substrate
 DG02975  XDH substrate
Metabolizing enzyme inhibitor
 DG01641  CYP2C8 inhibitor
 DG02952  AOX1 inhibitor
Remark
Therapeutic category: 6250
ATC code: J05AX27
Product: D09537<JP>
Efficacy
Antiviral, RNA polymerase inhibitor
Comment
Treatment of viral infection (broad-spectrum of anti-RNA virus activities)
Target
Influenza A virus RNA-directed RNA polymerase [KO:K19389]
  Pathway
ko03230  Viral genome structure
ko03240  Viral replication
ko05164  Influenza A
Metabolism
Enzyme: AOX1 [HSA:316]; XDH [HSA:7498]
Interaction
CYP inhibition: CYP2C8 [HSA:1558]
Enzyme inhibition: AOX1 [HSA:316]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AX Other antivirals
     J05AX27 Favipiravir
      D09537  Favipiravir (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D09537  Favipiravir (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antiviral
  DG03029  Anti-influenza virus agent
   D09537  Favipiravir
 Metabolizing enzyme substrate
  DG02953  AOX1 substrate
   D09537  Favipiravir
  DG02975  XDH substrate
   D09537  Favipiravir
 Metabolizing enzyme inhibitor
  DG01641  CYP2C8 inhibitor
   D09537  Favipiravir
  DG02952  AOX1 inhibitor
   D09537  Favipiravir
Drug classes [BR:br08332]
 Antiviral
  DG03029  Anti-influenza virus agent
   D09537  Favipiravir
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   Other inhibitor
    D09537  Favipiravir (JAN/USAN/INN) <JP>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   Other inhibitor
    D09537  Favipiravir (JAN/USAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09537
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09537
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09537
Other DBs
CAS: 259793-96-9
PubChem: 96026217
ChEBI: 134722
LigandBox: D09537
KCF data

ATOM        11
            1   C8x C    17.8500  -21.4200
            2   C8y C    17.8500  -20.0200
            3   N5x N    19.0400  -19.3200
            4   C8y C    20.3000  -20.0200
            5   C8y C    20.3000  -21.4200
            6   N5x N    19.0400  -22.1200
            7   X   F    16.6600  -19.3200
            8   O1a O    21.4900  -22.1200
            9   C5a C    21.4900  -19.3200
            10  N1a N    22.6800  -20.0200
            11  O5a O    21.4900  -17.9200
BOND        11
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     5   8 1
            9     4   9 1
            10    9  10 1
            11    9  11 2

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Ontology (9)   
   KEGG BRITE (9)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (6)   
   KEGG DGROUP (5)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (1)   
   KEGG ORTHOLOGY (1)   
All databases (20)   

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