KEGG   DRUG: Linifanib
Entry
D09635                      Drug                                   
Name
Linifanib (USAN/INN)
Formula
C21H18FN5O
Exact mass
375.1495
Mol weight
375.3989
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
Target
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
PDGFR [HSA:5156 5159] [KO:K04363 K05089]
CSF1R (FMS, CD115) [HSA:1436] [KO:K05090]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    D09635  Linifanib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFR
     D09635  Linifanib (USAN/INN)
   VEGFR family
    VEGFR1 (FLT1)
     D09635  Linifanib (USAN/INN)
    VEGFR2 (KDR)
     D09635  Linifanib (USAN/INN)
    VEGFR3 (FLT4)
     D09635  Linifanib (USAN/INN)
 Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    CSF1R (FMS, CD115)
     D09635  Linifanib (USAN/INN)
Other DBs
CAS: 796967-16-3
PubChem: 124490375
ChEBI: 91435
LigandBox: D09635
KCF data

ATOM        28
            1   C8x C    13.5100  -21.4200
            2   C8y C    13.5100  -22.8200
            3   C8x C    14.7224  -23.5200
            4   C8x C    15.9349  -22.8200
            5   C8y C    15.9349  -21.4200
            6   C8x C    14.7224  -20.7200
            7   N1b N    17.1660  -20.7090
            8   C5a C    18.3712  -21.4047
            9   N1b N    19.5535  -20.7219
            10  O5a O    18.3716  -22.8196
            11  C8y C    20.7475  -21.4112
            12  C8y C    20.7476  -22.8197
            13  C8x C    21.9601  -23.5196
            14  C8x C    23.1725  -22.8195
            15  C8y C    23.1723  -21.4109
            16  C8x C    21.9598  -20.7111
            17  X   F    19.5146  -23.5321
            18  C1a C    24.3790  -20.7141
            19  C8y C    12.2976  -23.5200
            20  C8y C    11.1021  -22.8296
            21  C8y C     9.8896  -23.5295
            22  C8x C     9.8894  -24.9295
            23  C8x C    11.0849  -25.6199
            24  C8x C    12.2974  -24.9200
            25  C8y C    10.8111  -21.4602
            26  N5x N     9.4188  -21.3137
            27  N4x N     8.8493  -22.5926
            28  N1a N    11.7192  -20.4518
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 2
            11    9  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18   12  17 1
            19   15  18 1
            20    2  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   19  24 1
            27   20  25 1
            28   25  26 2
            29   26  27 1
            30   21  27 1
            31   25  28 1

» Japanese version   » Back

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (12)   
   KEGG ORTHOLOGY (6)   
   KEGG GENES (6)   
All databases (18)   

Download RDF
DBGET integrated database retrieval system