| Entry |
|
|---|
| Name |
Lomitapide (USAN/INN) |
|---|
| Formula |
C39H37F6N3O2
|
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| Exact mass |
693.279
|
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| Mol weight |
693.7204
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Product (DG00362): | D09638<JP/US> |
|
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| Efficacy |
Antihyperlipidemic, Microsomal triglyceride transfer protein (MTTP) inhibitor |
|---|
| Comment |
Treatment of hypercholesterolemia and hypertriglyceridemia
|
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| Target |
|
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| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AX Other lipid modifying agents
C10AX12 Lomitapide
D09637 Lomitapide (USAN/INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG00362 Lomitapide
D09637 Lomitapide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00362 Lomitapide
D09637 Lomitapide
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Organismal systems
Digestive system
MTTP
D09637 Lomitapide (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D09637
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG00362 Lomitapide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00362 Lomitapide
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 50
1 C8y C 14.3500 -34.9300
2 C8y C 14.7700 -36.2600
3 C8y C 16.1700 -36.2600
4 C8y C 16.5900 -34.9300
5 C1z C 15.4700 -34.0900
6 C8x C 17.0800 -37.3100
7 C8x C 18.4800 -37.0300
8 C8x C 18.9000 -35.7000
9 C8x C 17.9900 -34.6500
10 C8x C 12.9500 -34.5800
11 C8x C 12.0400 -35.6300
12 C8x C 12.4600 -36.9600
13 C8x C 13.7900 -37.3100
14 C5a C 14.2800 -33.3900
15 N1b N 13.0900 -34.0900
16 O5a O 14.2800 -31.9900
17 C1b C 11.9000 -33.3900
18 C1d C 10.7100 -34.0900
19 X F 9.5200 -33.3900
20 X F 10.7100 -35.4900
21 X F 9.5200 -34.7900
22 C1b C 16.6600 -33.3900
23 C1b C 17.8500 -34.0900
24 C1b C 19.0400 -33.3900
25 C1b C 20.2300 -34.0900
26 N1y N 21.4200 -33.3900
27 C1x C 22.6381 -34.0801
28 C1x C 23.8448 -33.3703
29 C1y C 23.9034 -31.9703
30 C1x C 22.6153 -31.2802
31 C1x C 21.4086 -31.9900
32 N1b N 25.0857 -31.2957
33 C5a C 26.2728 -31.9893
34 C8y C 27.4712 -31.3055
35 O5a O 26.2657 -33.3899
36 C8y C 28.6501 -31.9941
37 C8x C 29.8660 -31.3003
38 C8x C 29.8732 -29.9003
39 C8x C 28.6944 -29.2117
40 C8x C 27.4084 -29.9055
41 C8y C 28.6429 -33.3899
42 C8x C 27.4172 -34.0893
43 C8x C 27.4100 -35.4893
44 C8y C 28.6189 -36.1955
45 C8x C 29.8446 -35.4961
46 C8x C 29.8517 -34.0961
47 C1d C 28.6118 -37.5899
48 X F 28.6047 -38.9898
49 X F 30.0118 -37.5899
50 X F 27.2118 -37.5899
BOND 55
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 1 5 1
6 3 6 2
7 6 7 1
8 7 8 2
9 8 9 1
10 4 9 2
11 1 10 2
12 10 11 1
13 11 12 2
14 12 13 1
15 2 13 2
16 14 5 1
17 14 15 1
18 14 16 2
19 15 17 1
20 17 18 1
21 18 19 1
22 18 20 1
23 18 21 1
24 22 23 1
25 22 5 1
26 23 24 1
27 24 25 1
28 25 26 1
29 26 27 1
30 27 28 1
31 28 29 1
32 29 30 1
33 30 31 1
34 26 31 1
35 29 32 1
36 32 33 1
37 33 34 1
38 33 35 2
39 34 36 2
40 36 37 1
41 37 38 2
42 38 39 1
43 39 40 2
44 34 40 1
45 36 41 1
46 41 42 2
47 42 43 1
48 43 44 2
49 44 45 1
50 45 46 2
51 41 46 1
52 44 47 1
53 47 48 1
54 47 49 1
55 47 50 1
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