KEGG   DRUG: Lomitapide mesylate
Entry
D09638                      Drug                                   
Name
Lomitapide mesylate (USAN);
Lomitapide mesilate (JAN);
Juxtapid (TN);
Lojuxta (TN)
Product
JUXTAPID (Amryt Pharmaceuticals DAC), JUXTAPID (Chiesi USA)
Formula
C39H37F6N3O2. CH4SO3
Exact mass
789.2671
Mol weight
789.8261
Structure
Simcomp
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2189
ATC code: C10AX12
Chemical structure group: DG00362
Product (DG00362): D09638<JP/US>
Efficacy
Antihyperlipidemic, Microsomal triglyceride transfer protein (MTTP) inhibitor
  Disease
Homozygous familial hypercholesterolemia [DS:H00155]
Comment
Treatment of hypercholesterolemia and hypertriglyceridemia
Target
MTTP [HSA:4547] [KO:K14463]
  Pathway
hsa04975  Fat digestion and absorption
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AX Other lipid modifying agents
     C10AX12 Lomitapide
      D09638  Lomitapide mesylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Other
   Lomitapide
    D09638  Lomitapide mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D09638  Lomitapide mesylate (USAN); Lomitapide mesilate (JAN)
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG00362  Lomitapide
    D09638  Lomitapide mesylate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00362  Lomitapide
     D09638  Lomitapide mesylate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01946  Hypolipidemic agent
   D09638  Lomitapide mesylate
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Organismal systems
   Digestive system
    MTTP
     D09638  Lomitapide mesylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09638
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09638
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09638
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09638
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09638
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG00362  Lomitapide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00362  Lomitapide
Other DBs
CAS: 202914-84-9
PubChem: 124490378
ChEBI: 72299
LigandBox: D09638
KCF data

ATOM        55
            1   C1a C    33.9659  -22.7313
            2   S4a S    35.3691  -22.7313
            3   O1d O    36.7724  -22.7313
            4   O1d O    35.3691  -21.3281
            5   O1d O    35.3691  -24.1345
            6   C8y C    15.7257  -23.3680
            7   C8y C    16.1467  -24.7013
            8   C8y C    17.5502  -24.7013
            9   C8y C    17.9712  -23.3680
            10  C1z C    16.8485  -22.5259
            11  C8x C    18.4625  -25.7539
            12  C8x C    19.8659  -25.4732
            13  C8x C    20.2870  -24.1399
            14  C8x C    19.3747  -23.0873
            15  C8x C    14.3222  -23.0171
            16  C8x C    13.4100  -24.0698
            17  C8x C    13.8310  -25.4031
            18  C8x C    15.1643  -25.7539
            19  C5a C    15.6555  -21.8242
            20  N1b N    14.4626  -22.5259
            21  O5a O    15.6555  -20.4207
            22  C1b C    13.2696  -21.8242
            23  C1d C    12.0767  -22.5259
            24  X   F    10.8837  -21.8242
            25  X   F    12.0767  -23.9294
            26  X   F    10.8837  -23.2277
            27  C1b C    18.0414  -21.8242
            28  C1b C    19.2344  -22.5259
            29  C1b C    20.4273  -21.8242
            30  C1b C    21.6203  -22.5259
            31  N1y N    22.8132  -21.8242
            32  C1x C    24.0062  -22.5259
            33  C1x C    25.2693  -21.8242
            34  C1y C    25.2693  -20.4207
            35  C1x C    24.0062  -19.7190
            36  C1x C    22.8132  -20.4207
            37  N1b N    26.4623  -19.7190
            38  C5a C    27.6552  -20.4207
            39  C8y C    28.8482  -19.7190
            40  O5a O    27.6552  -21.8242
            41  C8y C    30.0411  -20.4207
            42  C8x C    31.3042  -19.7190
            43  C8x C    31.3042  -18.3155
            44  C8x C    30.1113  -17.6138
            45  C8x C    28.8482  -18.3155
            46  C8y C    30.0411  -21.8242
            47  C8x C    28.8482  -22.5259
            48  C8x C    28.8482  -23.9294
            49  C8y C    30.0411  -24.6311
            50  C8x C    31.2341  -23.9294
            51  C8x C    31.2341  -22.5259
            52  C1d C    30.0411  -26.0346
            53  X   F    30.0411  -27.4381
            54  X   F    31.4446  -26.0346
            55  X   F    28.6376  -26.0346
BOND        59
            1     1   2 1
            2     2   3 1
            3     2   4 2
            4     2   5 2
            5     6   7 1
            6     7   8 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14    9  14 2
            15    6  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19    7  18 2
            20   19  10 1
            21   19  20 1
            22   19  21 2
            23   20  22 1
            24   22  23 1
            25   23  24 1
            26   23  25 1
            27   23  26 1
            28   27  28 1
            29   27  10 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   31  32 1
            34   32  33 1
            35   33  34 1
            36   34  35 1
            37   35  36 1
            38   31  36 1
            39   34  37 1
            40   37  38 1
            41   38  39 1
            42   38  40 2
            43   39  41 2
            44   41  42 1
            45   42  43 2
            46   43  44 1
            47   44  45 2
            48   39  45 1
            49   41  46 1
            50   46  47 2
            51   47  48 1
            52   48  49 2
            53   49  50 1
            54   50  51 2
            55   46  51 1
            56   49  52 1
            57   52  53 1
            58   52  54 1
            59   52  55 1

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