KEGG   DRUG: Lenvatinib
Entry
D09919                      Drug                                   
Name
Lenvatinib (USAN/INN)
Formula
C21H19ClN4O4
Exact mass
426.1095
Mol weight
426.853
Structure
Simcomp
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 substrate
Remark
ATC code: L01EX08
Chemical structure group: DG01362
Product (DG01362): D09920<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
FGFR [HSA:2260 2263 2261 2264] [KO:K04362 K05093 K05094 K05095]
RET [HSA:5979] [KO:K05126]
  Pathway
hsa04010  MAPK signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
hsa05216  Thyroid cancer
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Transporter: ABCB1 [HSA:5243]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX08 Lenvatinib
      D09919  Lenvatinib (USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG01362  Lenvatinib
     D09919  Lenvatinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01362  Lenvatinib
    D09919  Lenvatinib
 Transporter substrate
  DG01665  ABCB1 substrate
   DG01362  Lenvatinib
    D09919  Lenvatinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR
     D09919  Lenvatinib (USAN/INN)
   VEGFR family
    VEGFR1 (FLT1)
     D09919  Lenvatinib (USAN/INN)
    VEGFR2 (KDR)
     D09919  Lenvatinib (USAN/INN)
    VEGFR3 (FLT4)
     D09919  Lenvatinib (USAN/INN)
   RET family
    RET
     D09919  Lenvatinib (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09919
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09919
 Drug transporters
  D09919
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG01362  Lenvatinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG01362  Lenvatinib
 Transporter substrate
  DG01665  ABCB1 substrate
   DG01362  Lenvatinib
Other DBs
CAS: 417716-92-8
PubChem: 135626656
ChEBI: 85994
PDB-CCD: LEV[PDBj]
LigandBox: D09919
KCF data

ATOM        30
            1   C8y C     8.9600  -18.7600
            2   C8y C     8.9600  -20.1600
            3   C8x C    10.1724  -20.8600
            4   C8y C    11.3849  -20.1600
            5   C8y C    11.3849  -18.7600
            6   C8x C    10.1724  -18.0600
            7   C8y C    12.5973  -20.8600
            8   C8x C    13.8097  -20.1600
            9   C8x C    13.8097  -18.7600
            10  N5x N    12.5973  -18.0600
            11  O2a O    12.5973  -22.2600
            12  C8y C    13.8118  -22.9612
            13  C8x C    13.8117  -24.3598
            14  C8y C    15.0242  -25.0599
            15  C8y C    16.2366  -24.3599
            16  C8x C    16.2366  -22.9612
            17  C8x C    15.0242  -22.2612
            18  O2a O     7.7476  -18.0600
            19  C5a C     7.7476  -20.8600
            20  N1a N     6.5521  -20.1696
            21  O5a O     7.7475  -22.2598
            22  X   Cl   15.0241  -26.4598
            23  N1b N    17.4516  -25.0614
            24  C5a C    18.6483  -24.3703
            25  N1b N    19.8350  -25.0555
            26  O5a O    18.6485  -22.9603
            27  C1a C     6.5521  -18.7504
            28  C1y C    21.0267  -24.3674
            29  C1x C    22.4267  -24.3674
            30  C1x C    21.7267  -23.1549
BOND        33
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    1  18 1
            21    2  19 1
            22   19  20 1
            23   19  21 2
            24   14  22 1
            25   15  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 2
            29   18  27 1
            30   25  28 1
            31   28  29 1
            32   28  30 1
            33   30  29 1

» Japanese version   » Back

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   PDB-CCD (1)   
Gene (16)   
   KEGG ORTHOLOGY (8)   
   KEGG GENES (8)   
All databases (26)   

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