KEGG   DRUG: Efinaconazole
Entry
D10021                      Drug                                   
Name
Efinaconazole (JAN/USAN/INN);
Clenafin (TN);
Jublia (TN)
Product
JUBLIA (Bausch Health US LLC)
Formula
C18H22F2N4O
Exact mass
348.1762
Mol weight
348.3903
Structure
Class
Antifungal
 DG01523  Triazole antifungal
Remark
Therapeutic category: 6290
ATC code: D01AC19
Product: D10021<JP/US>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
  Disease
Onychomycosis [DS:H01316]
Comment
Triazole derivative
Target
sterol 14alpha-demethylase [KO:K05917]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AC Imidazole and triazole derivatives
     D01AC19 Efinaconazole
      D10021  Efinaconazole (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Topical Anti-infectives
   Antifungals, dermatological
    Efinaconazole
     D10021  Efinaconazole (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D10021  Efinaconazole (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antifungal
  DG01523  Triazole antifungal
   D10021  Efinaconazole
Drug classes [BR:br08332]
 Antifungal
  DG01523  Triazole antifungal
   D10021  Efinaconazole
Antimicrobials [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Triazole
    D10021  Efinaconazole (JAN/USAN/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Triazole
    D10021  Efinaconazole (JAN/USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10021
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10021
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10021
Other DBs
CAS: 164650-44-6
PubChem: 135626742
ChEBI: 82718
LigandBox: D10021
KCF data

ATOM        25
            1   C8x C    16.8000  -35.7000
            2   C8x C    16.8000  -37.1000
            3   C8y C    18.0124  -37.8000
            4   C8x C    19.2249  -37.1000
            5   C8y C    19.2249  -35.7000
            6   C8y C    18.0124  -35.0000
            7   X   F    18.0124  -39.1998
            8   X   F    20.4560  -34.9890
            9   C1d C    18.0124  -33.6002
            10  C1c C    16.7832  -32.8903
            11  C1b C    19.2080  -32.9098
            12  N1y N    15.5792  -33.5854
            13  C1a C    16.7834  -31.5001
            14  N4y N    19.2080  -31.5098
            15  C8x C    20.3266  -30.6967
            16  N5x N    19.8990  -29.3816
            17  C8x C    18.5161  -29.3819
            18  N5x N    18.0891  -30.6972
            19  C1x C    14.3963  -32.9023
            20  C1x C    13.1838  -33.6022
            21  C2y C    13.1837  -35.0022
            22  C1x C    14.3667  -35.6853
            23  C1x C    15.5791  -34.9854
            24  C2a C    11.9545  -35.7119
            25  O1a O    19.2249  -34.1602
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     3   7 1
            8     5   8 1
            9     6   9 1
            10    9  10 1
            11    9  11 1
            12   10  12 1
            13   10  13 1 #Down
            14   11  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   14  18 1
            20   12  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   12  23 1
            26   21  24 2
            27    9  25 1 #Up

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Ontology (10)   
   KEGG BRITE (10)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (1)   
   KEGG ORTHOLOGY (1)   
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