KEGG   DRUG: Cabozantinib
Entry
D10062                      Drug                                   
Name
Cabozantinib (USAN);
Cabometyx (TN);
Cometriq (TN)
Formula
C28H24FN3O5
Exact mass
501.17
Mol weight
501.5057
Structure
Simcomp
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
ATC code: L01EX07
Chemical structure group: DG01670
Product (DG01670): D10095<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Comment
Treatment of medullary thyroid carcinoma
Target
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
MET [HSA:4233] [KO:K05099]
AXL [HSA:558] [KO:K05115]
  Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX07 Cabozantinib
      D10062  Cabozantinib (USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG01670  Cabozantinib
     D10062  Cabozantinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   VEGFR family
    VEGFR2 (KDR)
     D10062  Cabozantinib (USAN)
   MET family
    MET
     D10062  Cabozantinib (USAN)
   AXL family
    AXL
     D10062  Cabozantinib (USAN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10062
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG01670  Cabozantinib
Other DBs
CAS: 849217-68-1
PubChem: 135626782
ChEBI: 72317
LigandBox: D10062
KCF data

ATOM        37
            1   C8y C    16.3800  -12.0400
            2   C8y C    16.3800  -13.4400
            3   C8y C    15.1900  -14.1400
            4   C8x C    13.9300  -13.4400
            5   C8x C    13.9300  -12.0400
            6   N5x N    15.1900  -11.3400
            7   C8x C    17.5700  -11.3400
            8   C8y C    18.8300  -12.0400
            9   C8y C    18.8300  -13.4400
            10  C8x C    17.5700  -14.1400
            11  O2a O    20.0200  -11.3400
            12  C1a C    21.2100  -12.0400
            13  O2a O    20.0200  -14.1400
            14  C1a C    21.2100  -13.4400
            15  O2a O    15.1900  -15.5400
            16  C8y C    16.4500  -16.2400
            17  C8x C    16.4500  -17.6400
            18  C8x C    17.6400  -18.3400
            19  C8y C    18.8300  -17.6400
            20  C8x C    18.8300  -16.1700
            21  C8x C    17.6400  -15.4700
            22  N1b N    20.0900  -18.2700
            23  C5a C    21.2800  -17.5700
            24  C1z C    22.5400  -18.2700
            25  O5a O    21.2800  -16.1700
            26  C5a C    23.7300  -17.5000
            27  N1b N    24.9200  -18.2000
            28  O5a O    23.7300  -16.1000
            29  C8y C    26.1100  -17.5000
            30  C8x C    27.3700  -18.2000
            31  C8x C    28.4900  -17.4300
            32  C8y C    28.4900  -16.0300
            33  C8x C    27.3000  -15.4000
            34  C8x C    26.1100  -16.1000
            35  X   F    29.7500  -15.4000
            36  C1x C    21.8400  -19.4600
            37  C1x C    23.2400  -19.4600
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    8  11 1
            13   11  12 1
            14    9  13 1
            15   13  14 1
            16    3  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   19  22 1
            25   22  23 1
            26   23  24 1
            27   23  25 2
            28   24  26 1
            29   26  27 1
            30   26  28 2
            31   27  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   32  33 1
            36   33  34 2
            37   29  34 1
            38   32  35 1
            39   36  37 1
            40   37  24 1
            41   24  36 1

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Ontology (4)   
   KEGG BRITE (4)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (6)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (3)   
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