KEGG   DRUG: Teriflunomide
Entry
D10172                      Drug                                   
Name
Teriflunomide (USAN);
Aubagio (TN)
Product
AUBAGIO (Genzyme Corporation)
  Generic
TERIFLUNOMIDE (AIZANT DRUG RESEARCH SOLUTIONS PVT), TERIFLUNOMIDE (Accord Healthcare), TERIFLUNOMIDE (Alembic Pharmaceuticals Limited), TERIFLUNOMIDE (Alembic Pharmaceuticals), TERIFLUNOMIDE (Amneal Pharmaceuticals NY LLC), TERIFLUNOMIDE (Apotex Corp), TERIFLUNOMIDE (Aurobindo Pharma Limited), TERIFLUNOMIDE (AvKARE), TERIFLUNOMIDE (Biocon Pharma), TERIFLUNOMIDE (Breckenridge Pharmaceutical), TERIFLUNOMIDE (Camber Pharmaceuticals), TERIFLUNOMIDE (Dr. Reddy's Laboratories), TERIFLUNOMIDE (Glenmark Pharmaceuticals), TERIFLUNOMIDE (MSN LABORATORIES PRIVATE LIMITED), TERIFLUNOMIDE (Mylan Pharmaceuticals), TERIFLUNOMIDE (Natco Pharma USA LLC), TERIFLUNOMIDE (SOLA Pharmaceuticals), TERIFLUNOMIDE (Sandoz), TERIFLUNOMIDE (Teva Pharmaceuticals), TERIFLUNOMIDE (Zydus Lifesciences Limited), TERIFLUNOMIDE (Zydus Pharmaceuticals USA)
Formula
C12H9F3N2O2
Exact mass
270.0616
Mol weight
270.2073
Structure
Simcomp
Remark
ATC code: L04AK02
Product: D10172<US>
Efficacy
Anti-inflammatory, Immunomodulator, Dihydroorotate dehydrogenase inhibitor
  Disease
Multiple sclerosis [DS:H01490]
Comment
Teriflunomide is the active metabolite of Leflunomide [DR:D00749]
Treatment of multiple sclerosis
Target
DHODH [HSA:1723] [KO:K00254]
  Pathway
hsa00240  Pyrimidine metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AK Dihydroorotate dehydrogenase (DHODH) inhibitors
     L04AK02 Teriflunomide
      D10172  Teriflunomide (USAN) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Multiple Sclerosis Agents
   Teriflunomide
    D10172  Teriflunomide (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    DHODH
     D10172  Teriflunomide (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10172
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10172
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10172
Other DBs
CAS: 163451-81-8
PubChem: 135626890
ChEBI: 68540
PDB-CCD: A26[PDBj]
LigandBox: D10172
KCF data

ATOM        19
            1   C8y C    21.6300  -21.7700
            2   C8x C    21.6300  -20.3700
            3   C8x C    22.8200  -19.6700
            4   C8y C    24.0800  -20.3700
            5   C8x C    24.0800  -21.7700
            6   C8x C    22.8200  -22.4700
            7   C1d C    25.2700  -19.6700
            8   N1b N    20.4400  -22.4700
            9   C5a C    19.2500  -21.7700
            10  C2c C    18.0600  -22.4700
            11  O5a O    19.2500  -20.3700
            12  C2c C    16.8700  -21.7700
            13  C3b C    18.0600  -23.8700
            14  N3a N    18.0600  -25.2700
            15  C1a C    15.6800  -22.4700
            16  O1a O    16.8700  -20.3700
            17  X   F    26.5300  -18.9700
            18  X   F    25.9700  -20.8600
            19  X   F    24.5700  -18.4800
BOND        19
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     1   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 2
            13   10  13 1
            14   13  14 3
            15   12  15 1
            16   12  16 1
            17    7  17 1
            18    7  18 1
            19    7  19 1

» Japanese version   » Back

  All links  
Ontology (6)   
   KEGG BRITE (6)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   PDB-CCD (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (13)   

Download RDF
DBGET integrated database retrieval system