| Entry |
|
|---|
| Name |
Trametinib (USAN) |
|---|
| Formula |
C26H23FIN5O4
|
|---|
| Exact mass |
615.0779
|
|---|
| Mol weight |
615.3948
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG03137 MEK inhibitor
|
|---|
| Remark |
| Product (DG00723): | D10176<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EE Mitogen-activated protein kinase (MEK) inhibitors
L01EE01 Trametinib
D10175 Trametinib (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG03137 MEK inhibitor
DG00723 Trametinib
D10175 Trametinib
Target-based classification of drugs [BR:br08310]
Protein kinases
Serine/threonine kinases
STE group
MAP2K1 (MEK1)
D10175 Trametinib (USAN)
MAP2K2 (MEK2)
D10175 Trametinib (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG03137 MEK inhibitor
DG00723 Trametinib
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 37
1 C8y C 23.0300 -23.1700
2 C8y C 23.0300 -24.5700
3 C8y C 24.2200 -25.2700
4 N4y N 25.4100 -24.5700
5 C8y C 25.4100 -23.1700
6 C8y C 24.2200 -22.4700
7 C8y C 24.2200 -21.0700
8 N4y N 23.0300 -20.3700
9 C8y C 21.7700 -21.0700
10 N4y N 21.7700 -22.4700
11 C1y C 23.0300 -18.9700
12 O5x O 25.4100 -20.3700
13 O5x O 20.5800 -20.3700
14 O5x O 24.2200 -26.7400
15 C1a C 26.6700 -25.3400
16 N1b N 26.6700 -22.4700
17 C8y C 27.8600 -23.1700
18 C8x C 27.8600 -24.5700
19 C8x C 29.1200 -25.2700
20 C8y C 30.3100 -24.5700
21 C8x C 30.3100 -23.1700
22 C8y C 29.1200 -22.4700
23 X F 29.1200 -21.0700
24 X I 31.5000 -25.2700
25 C1a C 21.7700 -25.2700
26 C8y C 20.5800 -23.1700
27 C8x C 19.3900 -22.4700
28 C8y C 18.2000 -23.1700
29 C8x C 18.2000 -24.6400
30 C8x C 19.3900 -25.2700
31 C8x C 20.5800 -24.5700
32 N1b N 16.9400 -22.4700
33 C5a C 15.7500 -23.1700
34 C1a C 14.5600 -22.4700
35 O5a O 15.7500 -24.5700
36 C1x C 23.7300 -17.7800
37 C1x C 22.3300 -17.7800
BOND 41
1 1 2 2
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 1 10 1
12 8 11 1
13 7 12 2
14 9 13 2
15 3 14 2
16 4 15 1
17 5 16 1
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 20 21 1
23 21 22 2
24 17 22 1
25 22 23 1
26 20 24 1
27 2 25 1
28 10 26 1
29 26 27 2
30 27 28 1
31 28 29 2
32 29 30 1
33 30 31 2
34 26 31 1
35 28 32 1
36 32 33 1
37 33 34 1
38 33 35 2
39 36 37 1
40 37 11 1
41 11 36 1
|
|---|
