| Entry |
|
|---|
| Name |
Tenofovir alafenamide (USAN/INN) |
|---|
| Abbr |
TAF |
|---|
| Formula |
C21H29N6O5P
|
|---|
| Exact mass |
476.1937
|
|---|
| Mol weight |
476.4659
|
|---|
| Structure |
|
|---|
| Class |
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
Transporter substrate
DG01665 ABCB1 substrate
DG01913 ABCG2 substrate
|
|---|
| Remark |
| Product (DG01223): | D01982<JP/US> D10605<JP/US> |
|
|---|
| Efficacy |
Antiviral, Reverse transcriptase inhibitor |
|---|
| Comment |
Active form of prodrug: Tenofovir [CPD: C17407]
|
|---|
| Target |
HBV reverse transcriptase [KO: K21037] |
|---|
| Pathway |
|
|---|
| Metabolism |
Transporter: ABCB1 [HSA: 5243], ABCG2 [HSA: 9429]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF13 Tenofovir alafenamide
D10428 Tenofovir alafenamide (USAN/INN)
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01223 Tenofovir
D10428 Tenofovir alafenamide
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG01223 Tenofovir
D10428 Tenofovir alafenamide
Transporter substrate
DG01665 ABCB1 substrate
D10428 Tenofovir alafenamide
DG01913 ABCG2 substrate
D10428 Tenofovir alafenamide
Antimicrobials [BR:br08307]
Antivirals
Genome replication inhibitor
HBV reverse transcriptase inhibitor
D10428 Tenofovir alafenamide (USAN/INN)
Antimicrobials abbreviations [BR:br08327]
Antivirals
Genome replication inhibitor
HBV reverse transcriptase inhibitor
D10428 Tenofovir alafenamide (USAN/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10428
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D10428
Prodrugs [br08324.html]
D10428
Drug groups [BR:br08330]
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01223 Tenofovir
DG03107 Anti-HIV agent
DG01656 HIV reverse transcriptase inhibitor
DG01223 Tenofovir
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 33
1 N5x N 22.5400 -22.2600
2 C8x C 22.5400 -23.7300
3 N5x N 21.3500 -24.4300
4 C8y C 20.0900 -23.7300
5 C8y C 20.0900 -22.2600
6 C8y C 21.3500 -21.5600
7 N4y N 18.7600 -24.1500
8 C8x C 17.9900 -23.0300
9 N5x N 18.7600 -21.8400
10 N1a N 21.3500 -20.1600
11 C1b C 18.7600 -25.5500
12 C1c C 17.5700 -26.2500
13 O2a O 16.3100 -25.5500
14 C1b C 15.2600 -26.2500
15 P1a P 14.0000 -25.5500
16 C1a C 17.5700 -27.5800
17 O2b O 12.7400 -24.8500
18 O3b O 14.7000 -24.2900
19 N1b N 12.8800 -26.7400
20 C8y C 11.3400 -24.8500
21 C8x C 10.6400 -23.6376
22 C8x C 9.2400 -23.6376
23 C8x C 8.5400 -24.8500
24 C8x C 9.2400 -26.0624
25 C8x C 10.6400 -26.0624
26 C1c C 12.8800 -28.1400
27 C7a C 11.6676 -28.8400
28 C1a C 14.0924 -28.8400
29 O7a O 10.4721 -28.1496
30 O6a O 11.6675 -30.2398
31 C1c C 9.2847 -28.8351
32 C1a C 8.0935 -28.1471
33 C1a C 9.2845 -30.2398
BOND 35
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 2
10 5 9 1
11 6 10 1
12 7 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 12 16 1 #Up
18 15 17 1 #Up
19 15 18 2
20 15 19 1 #Down
21 17 20 1
22 20 21 2
23 21 22 1
24 22 23 2
25 23 24 1
26 24 25 2
27 20 25 1
28 19 26 1
29 26 27 1
30 26 28 1 #Up
31 27 29 1
32 27 30 2
33 29 31 1
34 31 32 1
35 31 33 1
|
|---|
