KEGG   DRUG: Empagliflozin
Entry
D10459                      Drug                                   
Name
Empagliflozin (JAN/USAN/INN);
Jardiance (TN)
Product
JARDIANCE (A-S Medication Solutions), JARDIANCE (A-S Medication Solutions), JARDIANCE (A-S Medication Solutions), JARDIANCE (A-S Medication Solutions), JARDIANCE (Aphena Pharma Solutions - Tennessee), JARDIANCE (Boehringer Ingelheim Pharmaceuticals), JARDIANCE (Cardinal Health 107)
Formula
C23H27ClO7
Exact mass
450.1445
Mol weight
450.9093
Structure
Simcomp
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02924  UGT substrate
  DG03184  UGT1A3 substrate
  DG03186  UGT1A8 substrate
  DG03188  UGT1A9 substrate
  DG03190  UGT2B7 substrate
Transporter substrate
 DG01665  ABCB1 substrate
 DG01913  ABCG2 substrate
Remark
Same as: C22194
Therapeutic category: 2190 3969
ATC code: A10BK03
Product: D10459<JP/US>
Product (mixture): D10588<JP/US> D10752<US> D11856<US>
Efficacy
Antidiabetic, SGLT-2 inhibitor
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Phlorizin derivative
Treatment of type 2 diabetes
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT1A3 [HSA:54659], UGT1A8 [HSA:54576], UGT1A9 [HSA:54600]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
     A10BK03 Empagliflozin
      D10459  Empagliflozin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Sodium-Glucose Co-Transporter 2 (SGLT2) Inhbitor
    Empagliflozin
     D10459  Empagliflozin (JAN/USAN/INN)
 Cardiovascular Agents
  Sodium-Glucose Co-Transporter 2 Inhibitors (SGLT2i)
   Empagliflozin
    D10459  Empagliflozin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D10459  Empagliflozin (JAN/USAN/INN)
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D10459  Empagliflozin (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01794  SGLT2 inhibitor
    D10459  Empagliflozin
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG03184  UGT1A3 substrate
    D10459  Empagliflozin
   DG03186  UGT1A8 substrate
    D10459  Empagliflozin
   DG03188  UGT1A9 substrate
    D10459  Empagliflozin
   DG03190  UGT2B7 substrate
    D10459  Empagliflozin
 Transporter substrate
  DG01665  ABCB1 substrate
   D10459  Empagliflozin
  DG01913  ABCG2 substrate
   D10459  Empagliflozin
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01794  SGLT2 inhibitor
   D10459  Empagliflozin
  DG02044  Hypoglycemic agent
   D10459  Empagliflozin
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D10459  Empagliflozin (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10459
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10459
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10459
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10459
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10459
 Drug transporters
  D10459
Other DBs
CAS: 864070-44-0
PubChem: 172232552
ChEBI: 82720
PDB-CCD: 7R3[PDBj]
KCF data

ATOM        31
            1   C8y C    15.1431  -17.5925
            2   C8x C    15.1431  -18.9937
            3   C8x C    16.3342  -19.6944
            4   C8y C    17.5953  -18.9937
            5   C8y C    17.5953  -17.5925
            6   C8x C    16.3342  -16.8919
            7   C1b C    18.7864  -16.8919
            8   C8y C    20.0475  -17.5925
            9   C8x C    20.0475  -18.9937
            10  C8x C    21.2385  -19.6944
            11  C8y C    22.4296  -18.9937
            12  C8x C    22.4296  -17.5925
            13  C8x C    21.2385  -16.8919
            14  X   Cl   18.7864  -19.6944
            15  O2a O    23.6207  -19.6944
            16  C1y C    24.8117  -18.9937
            17  C1y C    13.9521  -16.8919
            18  O2x O    13.9521  -15.4906
            19  C1y C    12.6909  -14.7900
            20  C1y C    11.4999  -15.4906
            21  C1y C    11.4999  -16.8919
            22  C1y C    12.6909  -17.5925
            23  O1a O    12.6909  -18.9937
            24  O1a O    10.3088  -14.7900
            25  O1a O    10.3088  -17.5925
            26  C1b C    12.6909  -13.3888
            27  O1a O    13.9521  -12.6881
            28  C1x C    26.0964  -19.5532
            29  O2x O    27.0256  -18.5043
            30  C1x C    26.3151  -17.2965
            31  C1x C    24.9468  -17.5990
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    4  14 1
            16   11  15 1
            17   16  15 1 #Up
            18   17   1 1 #Up
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   21  20 1
            23   21  22 1
            24   22  17 1
            25   22  23 1 #Down
            26   20  24 1 #Down
            27   21  25 1 #Up
            28   19  26 1 #Up
            29   26  27 1
            30   16  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 1
            34   16  31 1

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