KEGG   DRUG: Lumacaftor and ivacaftor
Entry
D10685            Mixture   Drug                                   
Name
Lumacaftor and ivacaftor;
Orkambi (TN)
Product
ORKAMBI (Vertex Pharmaceuticals Incorporated)
Component
Lumacaftor [DR:D10134], Ivacaftor [DR:D09916]
Remark
ATC code: R07AX30
Product: D10685<US>
Efficacy
Cystic fibrosis treatment
  Disease
Cystic fibrosis (CFTR F508del homozygous mutation) [DS:H00218]
Comment
Treatment of cystic fibrosis (CF)
Target
CFTR* [HSA_VAR:1080v1] [HSA:1080] [KO:K05031]
  Pathway
hsa02010  ABC transporters
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
hsa04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R07 OTHER RESPIRATORY SYSTEM PRODUCTS
   R07A OTHER RESPIRATORY SYSTEM PRODUCTS
    R07AX Other respiratory system products
     R07AX30 Ivacaftor and lumacaftor
      D10685  Lumacaftor and ivacaftor <US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Cystic Fibrosis Agents
   Conductance Regulator Potentiator
    Lumacaftor/ Ivacaftor
     D10685  Lumacaftor and ivacaftor
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    CFTR* [HSA_VAR:1080v1]
     D10685  Lumacaftor and ivacaftor <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10685
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10685
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10685
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D10685
Other DBs
CAS: 1815566-23-4
PubChem: 254741646
ChEBI: 90950

» Japanese version   » Back

  All links  
Ontology (7)   
   KEGG BRITE (7)   
Network (1)   
   KEGG VARIANT (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (13)   

Download RDF
DBGET integrated database retrieval system