Entry |
|
Name |
Iptacopan (USAN/INN) |
Formula |
C25H30N2O4
|
Exact mass |
422.2206
|
Mol weight |
422.5167
|
Structure |
|
Class |
|
Remark |
Product (DG03207): | D12252<US> |
|
Efficacy |
Complement factor B inhibitor |
Comment |
Treatment of nephropathy, glomerulopathy, paroxysmal nocturnal hemoglobinuria and other conditions
|
Target |
|
Pathway |
hsa04610 | Complement and coagulation cascades |
|
Metabolism |
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 IMMUNOSUPPRESSANTS
L04A IMMUNOSUPPRESSANTS
L04AJ Complement inhibitors
L04AJ08 Iptacopan
D12251 Iptacopan (USAN/INN)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG03207 Iptacopan
D12251 Iptacopan
DG01644 CYP2D6 substrate
DG03207 Iptacopan
D12251 Iptacopan
DG02924 UGT substrate
DG03183 UGT1A1 substrate
DG03207 Iptacopan
D12251 Iptacopan
DG03184 UGT1A3 substrate
DG03207 Iptacopan
D12251 Iptacopan
DG03186 UGT1A8 substrate
DG03207 Iptacopan
D12251 Iptacopan
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Serine peptidases
CFB
D12251 Iptacopan (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D12251
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG03207 Iptacopan
DG01644 CYP2D6 substrate
DG03207 Iptacopan
DG02924 UGT substrate
DG03183 UGT1A1 substrate
DG03207 Iptacopan
DG03184 UGT1A3 substrate
DG03207 Iptacopan
DG03186 UGT1A8 substrate
DG03207 Iptacopan
|
Other DBs |
|
KCF data |
ATOM 31
1 N1y N 18.5164 -17.9525
2 C1x C 18.5164 -19.3555
3 C1x C 19.7314 -20.0570
4 C1y C 20.9465 -19.3555
5 C1x C 20.9465 -17.9525
6 C1y C 19.7314 -17.2510
7 C1b C 17.3014 -17.2510
8 C8y C 16.1033 -17.9429
9 C8y C 14.9134 -17.2559
10 C8y C 13.6984 -17.9575
11 C8x C 13.6985 -19.3605
12 C8x C 14.8883 -20.0474
13 C8y C 16.1033 -19.3459
14 C8x C 14.6217 -15.8836
15 C8x C 13.2264 -15.7370
16 N4x N 12.6557 -17.0187
17 O2a O 22.1803 -20.0680
18 C1b C 23.3881 -19.3709
19 C1a C 24.5729 -20.0551
20 C8y C 19.7314 -15.8482
21 C8x C 20.9296 -15.1562
22 C8x C 20.9294 -13.7532
23 C8y C 19.7143 -13.0519
24 C8x C 18.5162 -13.7438
25 C8x C 18.5163 -15.1468
26 C6a C 19.7142 -11.6390
27 O6a O 18.4952 -10.9354
28 O6a O 20.9253 -10.9397
29 O2a O 17.3435 -20.0619
30 C1b C 17.3435 -21.4649
31 C1a C 16.1329 -22.1639
BOND 34
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 1
7 1 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 9 14 1
16 14 15 2
17 15 16 1
18 10 16 1
19 4 17 1 #Up
20 17 18 1
21 18 19 1
22 6 20 1 #Down
23 20 21 2
24 21 22 1
25 22 23 2
26 23 24 1
27 24 25 2
28 20 25 1
29 23 26 1
30 26 27 1
31 26 28 2
32 13 29 1
33 29 30 1
34 30 31 1
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