Entry |
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Name |
4-oxoproline reductase;
cis-hydroxy-L-proline oxidase
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
cis-4-hydroxy-L-proline:NAD+ oxidoreductase (4-oxo-L-proline forming)
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Reaction(IUBMB) |
cis-4-hydroxy-L-proline + NAD+ = 4-oxo-L-proline + NADH + H+ [RN: R07146]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme, isolated from animals, is specific for 4-oxo-L-proline and cis-4-hydroxy-L-proline. It has no activity with trans-4-hydroxy-L-proline.
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History |
EC 1.1.1.104 created 1972, modified 2022
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Orthology |
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Genes |
PPS: | 100983278(BDH2) 100991105 |
LAV: | 100657244 100663603 104845941 |
GFR: | 102037474(BDH2) 102041424 |
BGAR: | 122924923 122925024(BDH2) |
SANH: | 107664555(bdh2) 107674194 |
SGH: | 107552725 107556803(bdh2) |
MASI: | 127444326 127444601 |
MANU: | 129444258 129444263 |
CCLU: | 121572331 123483404 |
BBEL: | 109464664 109479591 109481035 |
LPIC: | 129259193 129259738 |
PTRU: | 123516573 123516684 |
» show all
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Reference |
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Authors |
SMITH TE, MITOMA C. |
Title |
Partial purification and some properties of 4-ketoproline reductase. |
Journal |
J Biol Chem 237:1177-80 (1962) |
Reference |
|
Authors |
Kwiatkowski S, Bozko M, Zarod M, Witecka A, Kocdemir K, Jagielski AK, Drozak J. |
Title |
Recharacterization of the mammalian cytosolic type 2 (R)-beta-hydroxybutyrate dehydrogenase as 4-oxo-l-proline reductase (EC 1.1.1.104). |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.104 |
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